@article{80c366cb1ad94b66bbf97f1adc7d4c9d,
title = "Z/E stereoselective synthesis of β-bromo Baylis-Hillman ketones via a one-pot three-component X-C/C-C formation reaction",
abstract = "Highly stereoselective synthesis of (E)-β-bromo Baylis Hillman ketones has been achieved using a three-component X-C/C-C formation reaction. The synthesis involves the Michael-type addition of TiBr4 to α,β-acetylenic ketones without using any bases and carbonyl coupling with aldehydes. Modest yields (50-65%) and complete E/Z geometric selectivity have been realized for 10 examples.",
author = "Guigen Li and Wei, {Han Xun} and Gao, {Joe J.} and Jeremy Johnson",
note = "Funding Information: We gratefully acknowledge the National Institutes of Health, General Medical Sciences (GM-60261) and the Robert A. Welch Foundation (D-1361) for the generous support of this work; the National Science Foundation (CHE-9808436) for partial funding of the 500 MHz NMR spectrometer.",
year = "2002",
doi = "10.1081/SCC-120004273",
language = "English",
volume = "32",
pages = "1765--1773",
journal = "Synthetic Communications",
issn = "0039-7911",
number = "11",
}