The objective of this experiment was to determine the effect of yeast supplementation on the performance and health of newly weaned receiving cattle. Weaned crossbred steers (n = 184; initial BW = 203 ± 1 kg) were blocked by BW and randomly assigned to pen (4 pens/block; 5 to 6 animal/pen). Pens within a block were assigned randomly to 1 of 4 treatments (9 pens/treatment): 1) control (CON; no yeast); 2) live yeast (LY; 5 g/d per animal live yeast), 3) yeast cell wall (YCW; 5 g/d per animal yeast cell wall); 4) LY+YCW (5 g/d per animal LY and 5 g/d per animal YCW). Daily DMI was recorded and individual BW was collected every 14 d for 56 d. Data were analyzed using a randomized complete block design with the fixed effect of treatment and random effect of block. A subset of 24 steers (n = 6/treatment) was used on d 38 for a lipopolysaccharide challenge. Calves were fitted with jugular catheters and indwelling rectal-temperature measuring devices that measured rectal temperature. Cumulative DMI increased (P = 0.05) for the LY, YCW, and LY+YCW treatments compared with CON (6.02, 5.96, 5.89, and 5.47, kg/d, respectively). Before lipopolysaccharide challenge, CON calves had higher rectal temperature compared with LY+YCW (P = 0.01) and LY (P = 0.04) calves. Peak cortisol concentrations after lipopolysaccharide challenge were 26.5 ng/ mL greater (P = 0.04) in CON calves compared with LY+YCW calves. Results indicate that yeast supplements increased DMI and could improve cattle health during the receiving period.