What Can We Learn from Ambient Ionization Techniques?

Huanwen Chen, Gerardo Gamez Goytia, Renato Zenobi

Research output: Contribution to journalArticlepeer-review


Ambient mass spectrometry-mass spectrometric analysis with no or minimal effort for sample preparation-has experienced a very rapid development during the last 5 years, with many different methods now available for ionization. Here, we review its range of applications, the hurdles encountered for its quantitative use, and the proposed mechanisms for ion formation. Clearly, more effort needs to be put into investigation of matrix effects, into defining representative sampling of heterogeneous materials, and into understanding and controlling the underlying ionization mechanisms. Finally, we propose a concept to reduce the number of different acronyms describing very similar embodiments of ambient mass spectrometry. (J Am Soc Mass Spectrom 2009, 20, 1947-1963) (C) 2009 American Society for Mass Spectrometry
Original languageEnglish
Pages (from-to)1947-1963
JournalJournal of the American Society for Mass Spectrometry
StatePublished - Nov 2009


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