TY - JOUR
T1 - What Can We Learn from Ambient Ionization Techniques?
AU - Chen, Huanwen
AU - Gamez, Gerardo
AU - Zenobi, Renato
N1 - Funding Information:
The authors owe thanks to Mr. Bin Hu for his kind help in preparing some of the figures. The authors acknowledge support in part for this work by the Innovation Method Fund of China (2008IM040400) and by a grant from the Sino-Swiss Science and Technology Cooperation (no. IZLCZ 2123987).
PY - 2009/11
Y1 - 2009/11
N2 - Ambient mass spectrometry-mass spectrometric analysis with no or minimal effort for sample preparation-has experienced a very rapid development during the last 5 years, with many different methods now available for ionization. Here, we review its range of applications, the hurdles encountered for its quantitative use, and the proposed mechanisms for ion formation. Clearly, more effort needs to be put into investigation of matrix effects, into defining representative sampling of heterogeneous materials, and into understanding and controlling the underlying ionization mechanisms. Finally, we propose a concept to reduce the number of different acronyms describing very similar embodiments of ambient mass spectrometry.
AB - Ambient mass spectrometry-mass spectrometric analysis with no or minimal effort for sample preparation-has experienced a very rapid development during the last 5 years, with many different methods now available for ionization. Here, we review its range of applications, the hurdles encountered for its quantitative use, and the proposed mechanisms for ion formation. Clearly, more effort needs to be put into investigation of matrix effects, into defining representative sampling of heterogeneous materials, and into understanding and controlling the underlying ionization mechanisms. Finally, we propose a concept to reduce the number of different acronyms describing very similar embodiments of ambient mass spectrometry.
UR - http://www.scopus.com/inward/record.url?scp=70349769451&partnerID=8YFLogxK
U2 - 10.1016/j.jasms.2009.07.025
DO - 10.1016/j.jasms.2009.07.025
M3 - Article
C2 - 19748284
AN - SCOPUS:70349769451
VL - 20
SP - 1947
EP - 1963
JO - Journal of the American Society for Mass Spectrometry
JF - Journal of the American Society for Mass Spectrometry
SN - 1044-0305
IS - 11
ER -