Weighted multiplicity adjustments for animal carcinogenicity tests

P. H. Westfall, K. A. Soper, J. K. Haseman, D. Salsburg

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Sparse data is a difficulty in the analysis of animal carcinogenicity data: it is difficult to detect effects when the background tumor rates are low. The widely used 'Haseman rule' and its variants provide more power to tests with low background rates, while maintaining a degree of control over the global false positive rate. In this article we explore the use of these rules, finding global error rates that are unacceptably high for many animal Carcinogenicity studies. We provide alternative weighting methods that correct the deficiencies of the Haseman rule, and apply them to carcinogenicity data from a pharmaceutical company.

Original languageEnglish
Pages (from-to)23-44
Number of pages22
JournalJournal of Biopharmaceutical Statistics
Volume8
Issue number1
DOIs
StatePublished - 1998

Keywords

  • Haseman rule
  • Logrank test
  • Permutation test
  • Stepwise testing

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