Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: A prospective intervention trial

Mandeep Singh, Jaehoon Lee, Neil Gupta, Srinivas Gaddam, Bryan K. Smith, Sachin B. Wani, Debra K. Sullivan, Amit Rastogi, Ajay Bansal, Joseph E. Donnelly, Prateek Sharma

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

Objective: Weight gain is an important risk factor for gastroesophageal reflux disease (GERD); however, whether weight loss can lead to resolution of GERD symptoms is not clear. Our aim was to measure the impact of weight loss on GERD symptoms. Design and Methods: In a prospective cohort study at a tertiary referral center, overweight/obese subjects (BMI 25-39.9 kg/m2) were enrolled in a structured weight loss program.Weight loss strategies included dietary modifications, increased physical activity and behavioral changes. At baseline and at 6 months, BMI and waist circumference were measured and all participants completed a validated reflux disease questionnaire. Results: A total of 332 adult subjects, mean age 46 years and 66% women were prospectively enrolled. At baseline, the mean body weight, BMI, and waist circumference were 101 (618) kg, 35 (65) kg/m2 and 103 (613) cm. At 6 months, majority of the subjects (97%) lost weight (average weight loss: 13 6 7.7 kg) and as compared with baseline, there was a significant decrease in the overall prevalence of GERD (15 vs. 37%; P < 0.01) and the mean GERD symptom score (1.8 vs. 5.5; P < 0.01). Overall, 81% of the subjects had reduction in GERD symptom scores; 65% had complete resolution and 15% had partial resolution of reflux symptoms. There was a significant correlation between % body weight loss and reduction in GERD symptom scores (r = 0.17, P < 0.05). Conclusions: In conclusion, the overall prevalence of GERD symptoms is high (37%) in overweight and obese subjects. A structured weight loss program can lead to complete resolution of GERD symptoms in the majority of these subjects.

Original languageEnglish
Pages (from-to)284-290
Number of pages7
JournalObesity
Volume21
Issue number2
DOIs
StatePublished - Feb 2013

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