TY - JOUR
T1 - Visualizing temporal brain-state changes for fMRI using t-distributed stochastic neighbor embedding
AU - Parmar, Harshit
AU - Nutter, Brian
AU - Long, Rodney
AU - Antani, Sameer
AU - Mitra, Sunanda
N1 - Publisher Copyright:
© 2021 Society of Photo-Optical Instrumentation Engineers (SPIE).
PY - 2021/7/1
Y1 - 2021/7/1
N2 - Purpose: Currently, functional magnetic resonance imaging (fMRI) is the most commonly used technique for obtaining dynamic information about the brain. However, because of the complexity of the data, it is often difficult to directly visualize the temporal aspect of the fMRI data. Approach: We outline a t-distributed stochastic neighbor embedding (t-SNE)-based postprocessing technique that can be used for visualization of temporal information from a 4D fMRI data. Apart from visualization, we also show its utility in detection of major changes in the brain meta-states during the scan duration. Results: The t-SNE approach is able to detect brain-state changes from task to rest and vice versa for single- and multitask fMRI data. A temporal visualization can also be obtained for task and resting state fMRI data for assessing the temporal dynamics during the scan duration. Additionally, hemodynamic delay can be quantified by comparison of the detected brain-state changes with the experiment paradigm for task fMRI data. Conclusion: The t-SNE visualization can visualize help identify major brain-state changes from fMRI data. Such visualization can provide information about the degree of involvement and attentiveness of the subject during the scan and can be potentially utilized as a quality control for subject's performance during the scan.
AB - Purpose: Currently, functional magnetic resonance imaging (fMRI) is the most commonly used technique for obtaining dynamic information about the brain. However, because of the complexity of the data, it is often difficult to directly visualize the temporal aspect of the fMRI data. Approach: We outline a t-distributed stochastic neighbor embedding (t-SNE)-based postprocessing technique that can be used for visualization of temporal information from a 4D fMRI data. Apart from visualization, we also show its utility in detection of major changes in the brain meta-states during the scan duration. Results: The t-SNE approach is able to detect brain-state changes from task to rest and vice versa for single- and multitask fMRI data. A temporal visualization can also be obtained for task and resting state fMRI data for assessing the temporal dynamics during the scan duration. Additionally, hemodynamic delay can be quantified by comparison of the detected brain-state changes with the experiment paradigm for task fMRI data. Conclusion: The t-SNE visualization can visualize help identify major brain-state changes from fMRI data. Such visualization can provide information about the degree of involvement and attentiveness of the subject during the scan and can be potentially utilized as a quality control for subject's performance during the scan.
KW - brain-state changes
KW - dimensionality reduction
KW - functional MRI visualization
KW - t -distributed stochastic neighbor embedding
UR - http://www.scopus.com/inward/record.url?scp=85114314335&partnerID=8YFLogxK
U2 - 10.1117/1.JMI.8.4.046001
DO - 10.1117/1.JMI.8.4.046001
M3 - Article
AN - SCOPUS:85114314335
SN - 2329-4302
VL - 8
JO - Journal of Medical Imaging
JF - Journal of Medical Imaging
IS - 4
M1 - 046001
ER -