Visible-light-promoted intramolecular C-H amination in aqueous solution: Synthesis of carbazoles

Lizheng Yang, Yipin Zhang, Xiaodong Zou, Hongjian Lu, Guigen Li

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as a co-solvent, visible-light rather than various metals is used to facilitate the conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactive natural alkaloids, such as glycoborine, clausine C, clausine L, clausine H and clauszoline K, were synthesized efficiently with nitrogen as a sole byproduct. The reaction could be performed in water, acidic or alkaline buffer solutions, showing its potential for applications in biochemistry.

Original languageEnglish
Pages (from-to)1362-1366
Number of pages5
JournalGreen Chemistry
Volume20
Issue number6
DOIs
StatePublished - 2018

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