Versatile one-step one-pot direct aldol condensation promoted by MgI 2

Han Xun Wei, Kunyu Li, Qian Zhang, Richard L. Jasoni, Jiali Hu, Paul W. Paré

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A true one-step one-pot aldol-reaction procedure has been developed for the synthesis of β-hydroxy ketones and esters. The reaction can be run at room temperature by simply mixing four components in CH2Cl2, with medium-to-high yields of aldol products obtained after regular workup. Mechanistically, the process probably proceeds via Mg-enolate formation of the ketone or ester component, followed by addition to the electrophilic aldehyde.

Original languageEnglish
Pages (from-to)2354-2358
Number of pages5
JournalHelvetica Chimica Acta
Volume87
Issue number9
DOIs
StatePublished - 2004

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