Versatile one-step one-pot direct aldol condensation promoted by MgI 2

Han Xun Wei; Kunyu Li; Qian Zhang; Richard L. Jasoni; Jiali Hu; Paul W. Paré

doi:10.1002/hlca.200490211

Versatile one-step one-pot direct aldol condensation promoted by MgI ₂

Han Xun Wei, Kunyu Li, Qian Zhang, Richard L. Jasoni, Jiali Hu, Paul W. Paré

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A true one-step one-pot aldol-reaction procedure has been developed for the synthesis of β-hydroxy ketones and esters. The reaction can be run at room temperature by simply mixing four components in CH₂Cl₂, with medium-to-high yields of aldol products obtained after regular workup. Mechanistically, the process probably proceeds via Mg-enolate formation of the ketone or ester component, followed by addition to the electrophilic aldehyde.

Original language	English
Pages (from-to)	2354-2358
Number of pages	5
Journal	Helvetica Chimica Acta
Volume	87
Issue number	9
DOIs	https://doi.org/10.1002/hlca.200490211
State	Published - 2004

Access to Document

10.1002/hlca.200490211

Cite this

@article{1b1860e6cb3b4e36b9bce5ad6885bdde,

title = "Versatile one-step one-pot direct aldol condensation promoted by MgI 2",

abstract = "A true one-step one-pot aldol-reaction procedure has been developed for the synthesis of β-hydroxy ketones and esters. The reaction can be run at room temperature by simply mixing four components in CH2Cl2, with medium-to-high yields of aldol products obtained after regular workup. Mechanistically, the process probably proceeds via Mg-enolate formation of the ketone or ester component, followed by addition to the electrophilic aldehyde.",

author = "Wei, {Han Xun} and Kunyu Li and Qian Zhang and Jasoni, {Richard L.} and Jiali Hu and Par{\'e}, {Paul W.}",

year = "2004",

doi = "10.1002/hlca.200490211",

language = "English",

volume = "87",

pages = "2354--2358",

journal = "Helvetica Chimica Acta",

issn = "0018-019X",

number = "9",

}

TY - JOUR

T1 - Versatile one-step one-pot direct aldol condensation promoted by MgI 2

AU - Wei, Han Xun

AU - Li, Kunyu

AU - Zhang, Qian

AU - Jasoni, Richard L.

AU - Hu, Jiali

AU - Paré, Paul W.

PY - 2004

Y1 - 2004

N2 - A true one-step one-pot aldol-reaction procedure has been developed for the synthesis of β-hydroxy ketones and esters. The reaction can be run at room temperature by simply mixing four components in CH2Cl2, with medium-to-high yields of aldol products obtained after regular workup. Mechanistically, the process probably proceeds via Mg-enolate formation of the ketone or ester component, followed by addition to the electrophilic aldehyde.

AB - A true one-step one-pot aldol-reaction procedure has been developed for the synthesis of β-hydroxy ketones and esters. The reaction can be run at room temperature by simply mixing four components in CH2Cl2, with medium-to-high yields of aldol products obtained after regular workup. Mechanistically, the process probably proceeds via Mg-enolate formation of the ketone or ester component, followed by addition to the electrophilic aldehyde.

UR - http://www.scopus.com/inward/record.url?scp=5644223196&partnerID=8YFLogxK

U2 - 10.1002/hlca.200490211

DO - 10.1002/hlca.200490211

M3 - Article

AN - SCOPUS:5644223196

SN - 0018-019X

VL - 87

SP - 2354

EP - 2358

JO - Helvetica Chimica Acta

JF - Helvetica Chimica Acta

IS - 9

ER -

Versatile one-step one-pot direct aldol condensation promoted by MgI ₂

Abstract

Access to Document

Other files and links

Fingerprint

Cite this