Valvular Endothelial Cell Response to the Mechanical Environment—A Review

Nandini Deb; Carla M.R. Lacerda

doi:10.1007/s12013-021-01039-z

Valvular Endothelial Cell Response to the Mechanical Environment—A Review

Nandini Deb, Carla M.R. Lacerda

Chemical Engineering

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

Heart valve leaflets are complex structures containing valve endothelial cells, interstitial cells, and extracellular matrix. Heart valve endothelial cells sense mechanical stimuli, and communicate amongst themselves and the surrounding cells and extracellular matrix to maintain tissue homeostasis. In the presence of abnormal mechanical stimuli, endothelial cell communication is triggered in defense and such processes may eventually lead to cardiac disease progression. This review focuses on the role of mechanical stimuli on heart valve endothelial surfaces—from heart valve development and maintenance of tissue integrity to disease progression with related signal pathways involved in this process.

Original language	English
Pages (from-to)	695-709
Number of pages	15
Journal	Cell Biochemistry and Biophysics
Volume	79
Issue number	4
DOIs	https://doi.org/10.1007/s12013-021-01039-z
State	Published - Dec 2021

Keywords

Endothelial to mesenchymal transition
Heart valve
Mechanobiology
Shear stress
Tissue strain
Valve endothelial cells

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10.1007/s12013-021-01039-z

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@article{8530ae91092e4ad1ad8c63c523911d45,

title = "Valvular Endothelial Cell Response to the Mechanical Environment—A Review",

abstract = "Heart valve leaflets are complex structures containing valve endothelial cells, interstitial cells, and extracellular matrix. Heart valve endothelial cells sense mechanical stimuli, and communicate amongst themselves and the surrounding cells and extracellular matrix to maintain tissue homeostasis. In the presence of abnormal mechanical stimuli, endothelial cell communication is triggered in defense and such processes may eventually lead to cardiac disease progression. This review focuses on the role of mechanical stimuli on heart valve endothelial surfaces—from heart valve development and maintenance of tissue integrity to disease progression with related signal pathways involved in this process.",

keywords = "Endothelial to mesenchymal transition, Heart valve, Mechanobiology, Shear stress, Tissue strain, Valve endothelial cells",

author = "Nandini Deb and Lacerda, {Carla M.R.}",

note = "Funding Information: This work was supported by startup funds provided to C.M.R.L. by Texas Tech University. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

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doi = "10.1007/s12013-021-01039-z",

language = "English",

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T1 - Valvular Endothelial Cell Response to the Mechanical Environment—A Review

AU - Deb, Nandini

AU - Lacerda, Carla M.R.

N1 - Funding Information: This work was supported by startup funds provided to C.M.R.L. by Texas Tech University. Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2021/12

Y1 - 2021/12

N2 - Heart valve leaflets are complex structures containing valve endothelial cells, interstitial cells, and extracellular matrix. Heart valve endothelial cells sense mechanical stimuli, and communicate amongst themselves and the surrounding cells and extracellular matrix to maintain tissue homeostasis. In the presence of abnormal mechanical stimuli, endothelial cell communication is triggered in defense and such processes may eventually lead to cardiac disease progression. This review focuses on the role of mechanical stimuli on heart valve endothelial surfaces—from heart valve development and maintenance of tissue integrity to disease progression with related signal pathways involved in this process.

AB - Heart valve leaflets are complex structures containing valve endothelial cells, interstitial cells, and extracellular matrix. Heart valve endothelial cells sense mechanical stimuli, and communicate amongst themselves and the surrounding cells and extracellular matrix to maintain tissue homeostasis. In the presence of abnormal mechanical stimuli, endothelial cell communication is triggered in defense and such processes may eventually lead to cardiac disease progression. This review focuses on the role of mechanical stimuli on heart valve endothelial surfaces—from heart valve development and maintenance of tissue integrity to disease progression with related signal pathways involved in this process.

KW - Endothelial to mesenchymal transition

KW - Heart valve

KW - Mechanobiology

KW - Shear stress

KW - Tissue strain

KW - Valve endothelial cells

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U2 - 10.1007/s12013-021-01039-z

DO - 10.1007/s12013-021-01039-z

M3 - Review article

C2 - 34661855

AN - SCOPUS:85117252243

VL - 79

SP - 695

EP - 709

JO - Cell Biochemistry and Biophysics

JF - Cell Biochemistry and Biophysics

SN - 1085-9195

IS - 4

ER -

Valvular Endothelial Cell Response to the Mechanical Environment—A Review

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