TY - JOUR
T1 - Using prior information to allocate significance levels for multiple endpoints
AU - Westfall, Peter H.
AU - Krishen, Alok
AU - Stanley Young, S.
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/9/30
Y1 - 1998/9/30
N2 - We maximize power in a replicated clinical trial involving multiple endpoints by adjusting the individual significance levels for each hypothesis, using preliminary data to obtain the optimal adjustments. The levels are constrained to control the familywise error rate. Power is defined as the expected number of significances, where expectations are taken with respect to the posterior distributions of the non-centrality parameters under non-informative priors. Sample size requirements for the replicate study are given. Intuitive principles such as downweighting insignificant variables from a preliminary study and giving primary endpoints more emphasis are justifiable within the conceptual framework.
AB - We maximize power in a replicated clinical trial involving multiple endpoints by adjusting the individual significance levels for each hypothesis, using preliminary data to obtain the optimal adjustments. The levels are constrained to control the familywise error rate. Power is defined as the expected number of significances, where expectations are taken with respect to the posterior distributions of the non-centrality parameters under non-informative priors. Sample size requirements for the replicate study are given. Intuitive principles such as downweighting insignificant variables from a preliminary study and giving primary endpoints more emphasis are justifiable within the conceptual framework.
UR - http://www.scopus.com/inward/record.url?scp=0032582080&partnerID=8YFLogxK
U2 - 10.1002/(SICI)1097-0258(19980930)17:18<2107::AID-SIM910>3.0.CO;2-W
DO - 10.1002/(SICI)1097-0258(19980930)17:18<2107::AID-SIM910>3.0.CO;2-W
M3 - Article
C2 - 9789917
AN - SCOPUS:0032582080
VL - 17
SP - 2107
EP - 2119
JO - Statistics in Medicine
JF - Statistics in Medicine
SN - 0277-6715
IS - 18
ER -