A 4-yr trial was initiated in January 2000 to evaluate cow-calf performance on mixed-species pasture systems consisting of (i) endophyte-infected tall fescue (E+; Festuca arundinacea Schreb.) diluted by approximately 50% with common bermudagrass [Cynodon dactylon (L.) Pers.] and other forages; (ii) endophyte-free tall fescue (E-) overseeded into dormant common bermudagrass; and (iii) orchardgrass (OG; Dactylis glomerata L.) established under the same conditions as E-. The E- and OG pastures were grazed with either twice weekly (2W) or twice monthly (2M) rotation schedules, while pastures with E+ were grazed with 2M only. Actual weaning weights tended to he greater (P = 0.096), and age-adjusted 205-d weaning weights and average daily gain from hirth to weaning were greater (P ≤ 0.035) for calves raised on low-toxicity (E- or OG) pastures compared to those raised on E+. Over 4 yr, calves raised on low-toxicity pastures exhibited 22- and 24-kg advantages in actual and 205-d adjusted weaning weights, respectively, compared to those raised on E+. Cows grazing OG and E- pastures exhibited greater (P ≤ 0.021) body weights and body condition scores (BCS) at calving than cows grazing E+ pastures. Furthermore, reductions in body weight and BCS between calving and weaning tended to be greater (P ≤ 0.088) for cows grazing E+ pastures. Calf performance was improved consistently by these low-toxicity pasture systems, but management requirements may limit adaptation by producers.