Ursolic acid-induced elevation of serum irisin augments muscle strength during resistance training in men

Hyun Seok Bang, Dae Yun Seo, Yong Min Chung, Kyoung Mo Oh, Jung Jun Park, Figueroa Arturo, Seung Hun Jeong, Nari Kim, Jin Han

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on skeletal muscle development and related factors in men. Sixteen healthy male participants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m2) were randomly assigned to RT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of intervention consisting of 5 sets of 26 exercises, with 10 ∼ 15 repetitions at 60 ∼ 80% of 1 repetition maximum and a 60 ∼ 90-s rest interval between sets, performed 6 times/week. UA or placebo was orally ingested as 1 capsule 3 times/day for 8 weeks. The following factors were measured pre-and post-intervention: body composition, insulin, insulin-like growth factor-1 (IGF-1), irisin, and skeletal muscle strength. Body fat percentage was significantly decreased (p< 0.001) in the RT+UA group, despite body weight, body mass index, lean body mass, glucose, and insulin levels remaining unchanged. IGF-1 and irisin were significantly increased compared with baseline levels in the RT+UA group (p< 0.05). Maximal right and left extension (p< 0.01), right flexion (p< 0.05), and left flexion (p< 0.001) were significantly increased compared with baseline levels in the RT+UA group. These findings suggest that UA-induced elevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strength during RT.

Original languageEnglish
Pages (from-to)441-446
Number of pages6
JournalKorean Journal of Physiology and Pharmacology
Volume18
Issue number5
DOIs
StatePublished - Oct 1 2014

Keywords

  • IGF-1
  • Irisin
  • Muscle strength
  • Resistance training
  • Ursolic acid

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