TY - JOUR
T1 - Ursolic acid-induced elevation of serum irisin augments muscle strength during resistance training in men
AU - Bang, Hyun Seok
AU - Seo, Dae Yun
AU - Chung, Yong Min
AU - Oh, Kyoung Mo
AU - Park, Jung Jun
AU - Arturo, Figueroa
AU - Jeong, Seung Hun
AU - Kim, Nari
AU - Han, Jin
PY - 2014/10/1
Y1 - 2014/10/1
N2 - Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on skeletal muscle development and related factors in men. Sixteen healthy male participants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m2) were randomly assigned to RT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of intervention consisting of 5 sets of 26 exercises, with 10 ∼ 15 repetitions at 60 ∼ 80% of 1 repetition maximum and a 60 ∼ 90-s rest interval between sets, performed 6 times/week. UA or placebo was orally ingested as 1 capsule 3 times/day for 8 weeks. The following factors were measured pre-and post-intervention: body composition, insulin, insulin-like growth factor-1 (IGF-1), irisin, and skeletal muscle strength. Body fat percentage was significantly decreased (p< 0.001) in the RT+UA group, despite body weight, body mass index, lean body mass, glucose, and insulin levels remaining unchanged. IGF-1 and irisin were significantly increased compared with baseline levels in the RT+UA group (p< 0.05). Maximal right and left extension (p< 0.01), right flexion (p< 0.05), and left flexion (p< 0.001) were significantly increased compared with baseline levels in the RT+UA group. These findings suggest that UA-induced elevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strength during RT.
AB - Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants, can promote skeletal muscle development. We measured the effect of resistance training (RT) with/without UA on skeletal muscle development and related factors in men. Sixteen healthy male participants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m2) were randomly assigned to RT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of intervention consisting of 5 sets of 26 exercises, with 10 ∼ 15 repetitions at 60 ∼ 80% of 1 repetition maximum and a 60 ∼ 90-s rest interval between sets, performed 6 times/week. UA or placebo was orally ingested as 1 capsule 3 times/day for 8 weeks. The following factors were measured pre-and post-intervention: body composition, insulin, insulin-like growth factor-1 (IGF-1), irisin, and skeletal muscle strength. Body fat percentage was significantly decreased (p< 0.001) in the RT+UA group, despite body weight, body mass index, lean body mass, glucose, and insulin levels remaining unchanged. IGF-1 and irisin were significantly increased compared with baseline levels in the RT+UA group (p< 0.05). Maximal right and left extension (p< 0.01), right flexion (p< 0.05), and left flexion (p< 0.001) were significantly increased compared with baseline levels in the RT+UA group. These findings suggest that UA-induced elevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strength during RT.
KW - IGF-1
KW - Irisin
KW - Muscle strength
KW - Resistance training
KW - Ursolic acid
UR - http://www.scopus.com/inward/record.url?scp=84910137312&partnerID=8YFLogxK
U2 - 10.4196/kjpp.2014.18.5.441
DO - 10.4196/kjpp.2014.18.5.441
M3 - Article
AN - SCOPUS:84910137312
VL - 18
SP - 441
EP - 446
JO - Korean Journal of Physiology and Pharmacology
JF - Korean Journal of Physiology and Pharmacology
SN - 1226-4512
IS - 5
ER -