Unique supramolecular complex of diclofenac: Structural robustness, crystal-to-crystal solvent exchange, and mechanochemical synthesis

Qixuan Zheng, Samantha L. Rood, Daniel K. Unruh, Kristin M. Hutchins

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We describe an unexpected, cyclic supramolecular complex that results from self-assembly of the nonsteroidal anti-inflammatory drug, diclofenac and 4,4′-azopyridine. The cycles self-assemble into 1D columns occupied by solvent, which can be removed at elevated temperatures (>100 °C) while retaining crystallinity. The complex exhibits solvent exchange ability that occurs through crystal-to-crystal transformations. Finally, the complex can be synthesized using mechanochemistry. Materials exhibiting the structural framework and robustness described here could be applied to removal of hazardous materials or undesirable solvents.

Original languageEnglish
Pages (from-to)7639-7642
Number of pages4
JournalChemical Communications
Volume55
Issue number53
DOIs
StatePublished - 2019

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