@article{2a32c0cb837e41298ba2280d186e0c4f,
title = "Unexpected isocyanide-based three-component bicyclization for the stereoselective synthesis of densely functionalized pyrano[3,4-c]pyrroles",
abstract = "A novel three-component bicyclization strategy for the efficient synthesis of densely functionalized pyrano[3,4-c]pyrroles has been established from readily accessible 3-aroylacrylic acids, dialkyl acetylenedicarboxylates and isocyanides. The reaction pathway involves Huisgen 1,3-dipole formation, Passerini-type reaction, Mumm rearrangement and an oxo-Diels-Alder reaction sequence, resulting in continuous multiple bond-forming events including C-N, C-O and C-H bonds to rapidly build up molecular complexity.",
author = "Qian Gao and Hao, {Wen Juan} and Feng Liu and Tu, {Shu Jiang} and Wang, {Shu Liang} and Guigen Li and Bo Jiang",
note = "Funding Information: We are grateful for financial support from the NSFC (No. 21232004, 21332005, 21272095, and 21472071), PAPD of Jiangsu Higher Education Institutions, Robert A. Welch Foundation (D-1361, USA) and NIH (R33DA031860, USA), the Outstanding Youth Fund of JSNU (YQ2015003), NSF of Jiangsu Province (BK20151163), and the Open Foundation of Jiangsu Key Laboratory (K201505). Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",
year = "2016",
doi = "10.1039/c5cc08071a",
language = "English",
volume = "52",
pages = "900--903",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry (RSC)",
number = "5",
}