Underlying mechanisms of circular calcium wave propagation in rat ventricular myocytes

Theodore Wiesner, Sai Subramanian, Sandor Gyorke, Serge ViatchenkoKarpinski, Valeriy Lukyanenko

Research output: Contribution to journalConference articlepeer-review


It was hypothesized that subcellular organelles counteracted the higher release site density along Z-lines by acting as transverse diffusion barriers. The ratio of the longitudinal diffusion coefficient to the transverse coefficient was 2.6, supporting the hypothesis of transverse diffusion barriers. The combination of release sites clustered at the Zlines and a transverse diffusion coefficient 50% fo that in the longitudinal dirrection generated elliptical waves of eccentricity 4/3. Introducing putative release sites between the Z-lines at a density 20% of that on the Z-lines produced circular waves. The experiments and simulations support the presence of transverse diffusion barriers, and possibly intermediate release sites also.

Original languageEnglish
Pages (from-to)S-59
JournalAnnals of Biomedical Engineering
Issue numberSUPPL. 1
StatePublished - 2000
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000


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