TY - JOUR
T1 - Underlying mechanisms of circular calcium wave propagation in rat ventricular myocytes
AU - Wiesner, Theodore
AU - Subramanian, Sai
AU - Gyorke, Sandor
AU - ViatchenkoKarpinski, Serge
AU - Lukyanenko, Valeriy
PY - 2000
Y1 - 2000
N2 - It was hypothesized that subcellular organelles counteracted the higher release site density along Z-lines by acting as transverse diffusion barriers. The ratio of the longitudinal diffusion coefficient to the transverse coefficient was 2.6, supporting the hypothesis of transverse diffusion barriers. The combination of release sites clustered at the Zlines and a transverse diffusion coefficient 50% fo that in the longitudinal dirrection generated elliptical waves of eccentricity 4/3. Introducing putative release sites between the Z-lines at a density 20% of that on the Z-lines produced circular waves. The experiments and simulations support the presence of transverse diffusion barriers, and possibly intermediate release sites also.
AB - It was hypothesized that subcellular organelles counteracted the higher release site density along Z-lines by acting as transverse diffusion barriers. The ratio of the longitudinal diffusion coefficient to the transverse coefficient was 2.6, supporting the hypothesis of transverse diffusion barriers. The combination of release sites clustered at the Zlines and a transverse diffusion coefficient 50% fo that in the longitudinal dirrection generated elliptical waves of eccentricity 4/3. Introducing putative release sites between the Z-lines at a density 20% of that on the Z-lines produced circular waves. The experiments and simulations support the presence of transverse diffusion barriers, and possibly intermediate release sites also.
UR - http://www.scopus.com/inward/record.url?scp=0034505240&partnerID=8YFLogxK
M3 - Conference article
AN - SCOPUS:0034505240
SN - 0090-6964
VL - 28
SP - S-59
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - SUPPL. 1
T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society
Y2 - 12 October 2000 through 14 October 2000
ER -