TY - JOUR
T1 - Ubiquitination and sumoylation in HIV infection
T2 - Friends and foes
AU - Colomer-Lluch, Marta
AU - Castro-Gonzalez, Sergio
AU - Serra-Moreno, Ruth
N1 - Funding Information:
We would like to thank Brendan Allison (Texas Tech University) for critical revision of this review article and his helpful comments. This work has been supported in part by NIH/NIAID R21 AI106400, R21 AI138589 and Texas Tech University.
Publisher Copyright:
© 2020, Caister Academic Press. All rights reserved.
PY - 2020
Y1 - 2020
N2 - As intracellular parasites, viruses hijack the cellular machinery to facilitate their replication and spread. This includes favouring the expression of their viral genes over host genes, appropriation of cellular molecules, and manipulation of signalling pathways, including the post-translational machinery. HIV, the causative agent of AIDS, is notorious for using post-translational modifications to generate infectious particles. Here, we discuss the mechanisms by which HIV usurps the ubiquitin and SUMO pathways to modify both viral and host factors to achieve a productive infection, and also how the host innate sensing system uses these post-translational modifications to hinder HIV replication.
AB - As intracellular parasites, viruses hijack the cellular machinery to facilitate their replication and spread. This includes favouring the expression of their viral genes over host genes, appropriation of cellular molecules, and manipulation of signalling pathways, including the post-translational machinery. HIV, the causative agent of AIDS, is notorious for using post-translational modifications to generate infectious particles. Here, we discuss the mechanisms by which HIV usurps the ubiquitin and SUMO pathways to modify both viral and host factors to achieve a productive infection, and also how the host innate sensing system uses these post-translational modifications to hinder HIV replication.
UR - http://www.scopus.com/inward/record.url?scp=85075508406&partnerID=8YFLogxK
U2 - 10.21775/cimb.035.159
DO - 10.21775/cimb.035.159
M3 - Article
C2 - 31422939
AN - SCOPUS:85075508406
VL - 35
SP - 159
EP - 194
JO - Current Issues in Molecular Biology
JF - Current Issues in Molecular Biology
SN - 1467-3037
ER -