Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells

Eduardo Reátegui; Nicola Aceto; Eugene J. Lim; James P. Sullivan; Anne E. Jensen; Mahnaz Zeinali; Joseph M. Martel; Alexander J. Aranyosi; Wei Li; Steven Castleberry; Aditya Bardia; Lecia V. Sequist; Daniel A. Haber; Shyamala Maheswaran; Paula T. Hammond; Mehmet Toner; Shannon L. Stott

doi:10.1002/adma.201404677

Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells

Eduardo Reátegui, Nicola Aceto, Eugene J. Lim, James P. Sullivan, Anne E. Jensen, Mahnaz Zeinali, Joseph M. Martel, Alexander J. Aranyosi, Wei Li, Steven Castleberry, Aditya Bardia, Lecia V. Sequist, Daniel A. Haber, Shyamala Maheswaran, Paula T. Hammond, Mehmet Toner, Shannon L. Stott

Chemical Engineering

Research output: Contribution to journal › Article › peer-review

140 Scopus citations

Abstract

A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of micro fluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. (Chemical Equation Presented).

Original language	English
Pages (from-to)	1593-1599
Number of pages	7
Journal	Advanced Materials
Volume	27
Issue number	9
DOIs	https://doi.org/10.1002/adma.201404677
State	Published - Mar 4 2015

Keywords

Circulating tumor cells
Circulating tumor clusters
Microfluidics
Nanostructured coatings
Single cell sequencing

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10.1002/adma.201404677

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Reátegui, E., Aceto, N., Lim, E. J., Sullivan, J. P., Jensen, A. E., Zeinali, M., Martel, J. M., Aranyosi, A. J., Li, W., Castleberry, S., Bardia, A., Sequist, L. V., Haber, D. A., Maheswaran, S., Hammond, P. T., Toner, M., & Stott, S. L. (2015). Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells. Advanced Materials, 27(9), 1593-1599. https://doi.org/10.1002/adma.201404677

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title = "Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells",

abstract = "A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of micro fluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. (Chemical Equation Presented).",

keywords = "Circulating tumor cells, Circulating tumor clusters, Microfluidics, Nanostructured coatings, Single cell sequencing",

author = "Eduardo Re{\'a}tegui and Nicola Aceto and Lim, {Eugene J.} and Sullivan, {James P.} and Jensen, {Anne E.} and Mahnaz Zeinali and Martel, {Joseph M.} and Aranyosi, {Alexander J.} and Wei Li and Steven Castleberry and Aditya Bardia and Sequist, {Lecia V.} and Haber, {Daniel A.} and Shyamala Maheswaran and Hammond, {Paula T.} and Mehmet Toner and Stott, {Shannon L.}",

note = "Publisher Copyright: {\textcopyright} 2015 Wiley-VCH Verlag GmbH & Co. KGaA.",

year = "2015",

month = mar,

day = "4",

doi = "10.1002/adma.201404677",

language = "English",

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Reátegui, E, Aceto, N, Lim, EJ, Sullivan, JP, Jensen, AE, Zeinali, M, Martel, JM, Aranyosi, AJ, Li, W, Castleberry, S, Bardia, A, Sequist, LV, Haber, DA, Maheswaran, S, Hammond, PT, Toner, M & Stott, SL 2015, 'Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells', Advanced Materials, vol. 27, no. 9, pp. 1593-1599. https://doi.org/10.1002/adma.201404677

TY - JOUR

T1 - Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells

AU - Reátegui, Eduardo

AU - Aceto, Nicola

AU - Lim, Eugene J.

AU - Sullivan, James P.

AU - Jensen, Anne E.

AU - Zeinali, Mahnaz

AU - Martel, Joseph M.

AU - Aranyosi, Alexander J.

AU - Li, Wei

AU - Castleberry, Steven

AU - Bardia, Aditya

AU - Sequist, Lecia V.

AU - Haber, Daniel A.

AU - Maheswaran, Shyamala

AU - Hammond, Paula T.

AU - Toner, Mehmet

AU - Stott, Shannon L.

PY - 2015/3/4

Y1 - 2015/3/4

N2 - A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of micro fluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. (Chemical Equation Presented).

AB - A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of micro fluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. (Chemical Equation Presented).

KW - Circulating tumor cells

KW - Circulating tumor clusters

KW - Microfluidics

KW - Nanostructured coatings

KW - Single cell sequencing

UR - http://www.scopus.com/inward/record.url?scp=84923815724&partnerID=8YFLogxK

U2 - 10.1002/adma.201404677

DO - 10.1002/adma.201404677

M3 - Article

C2 - 25640006

AN - SCOPUS:84923815724

SN - 0935-9648

VL - 27

SP - 1593

EP - 1599

JO - Advanced Materials

JF - Advanced Materials

IS - 9

ER -

Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells

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Keywords

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