Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells

Eduardo Reátegui, Nicola Aceto, Eugene J. Lim, James P. Sullivan, Anne E. Jensen, Mahnaz Zeinali, Joseph M. Martel, Alexander J. Aranyosi, Wei Li, Steven Castleberry, Aditya Bardia, Lecia V. Sequist, Daniel A. Haber, Shyamala Maheswaran, Paula T. Hammond, Mehmet Toner, Shannon L. Stott

Research output: Contribution to journalArticlepeer-review

109 Scopus citations

Abstract

A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of micro fluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)1593-1599
Number of pages7
JournalAdvanced Materials
Volume27
Issue number9
DOIs
StatePublished - Mar 4 2015

Keywords

  • Circulating tumor cells
  • Circulating tumor clusters
  • Microfluidics
  • Nanostructured coatings
  • Single cell sequencing

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