Tumor ablation due to inhomogeneous anisotropic diffusion in generic three-dimensional topologies

Erdi Kara, Aminur Rahman, Eugenio Aulisa, Souparno Ghosh

Research output: Contribution to journalArticlepeer-review

Abstract

In recent decades computer-aided technologies have become prevalent in medicine, however, cancer drugs are often only tested on in vitro cell lines from biopsies. We derive a full three-dimensional model of inhomogeneous -anisotropic diffusion in a tumor region coupled to a binary population model, which simulates in vivo scenarios faster than traditional cell-line tests. The diffusion tensors are acquired using diffusion tensor magnetic resonance imaging from a patient diagnosed with glioblastoma multiform. Then we numerically simulate the full model with finite element methods and produce drug concentration heat maps, apoptosis hotspots, and dose-response curves. Finally, predictions are made about optimal injection locations and volumes, which are presented in a form that can be employed by doctors and oncologists.

Original languageEnglish
Article number062425
JournalPhysical Review E
Volume102
Issue number6
DOIs
StatePublished - Dec 30 2020

Fingerprint

Dive into the research topics of 'Tumor ablation due to inhomogeneous anisotropic diffusion in generic three-dimensional topologies'. Together they form a unique fingerprint.

Cite this