Transient Ligand-Enabled Transition Metal-Catalyzed C−H Functionalization

Ben Niu, Ke Yang, Brianna Lawrence, Haibo Ge

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Transition metal-catalyzed C−H bond functionalization is among the most efficient and powerful strategies in synthetic organic chemistry to derivatize otherwise inert sites of organic molecules for the construction of C−C and C−heteroatom bonds. However, additional steps are often required to install the directing groups to realize selective C−H bond functionalization of the substrates. These tedious steps run counter to the step-economical nature of the C−H activation. In contrast, direct functionalization of the substrate by using transient ligands avoids the unnecessary steps for the pre-functionalization of the substrates. This Minireview provides a short overview of the major progress made in this field for C−H functionalization at sp2 and sp3 carbon centers with different transient working modes, including covalent, hydrogen, and ionic bonds.

Original languageEnglish
Pages (from-to)2955-2969
Number of pages15
JournalChemSusChem
Volume12
Issue number13
DOIs
StatePublished - Jul 5 2019

Keywords

  • C−H activation
  • homogeneous catalysis
  • ligand effects
  • organic synthesis
  • transition metals

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