Abstract
Transition metal-catalyzed C−H bond functionalization is among the most efficient and powerful strategies in synthetic organic chemistry to derivatize otherwise inert sites of organic molecules for the construction of C−C and C−heteroatom bonds. However, additional steps are often required to install the directing groups to realize selective C−H bond functionalization of the substrates. These tedious steps run counter to the step-economical nature of the C−H activation. In contrast, direct functionalization of the substrate by using transient ligands avoids the unnecessary steps for the pre-functionalization of the substrates. This Minireview provides a short overview of the major progress made in this field for C−H functionalization at sp2 and sp3 carbon centers with different transient working modes, including covalent, hydrogen, and ionic bonds.
Original language | English |
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Pages (from-to) | 2955-2969 |
Number of pages | 15 |
Journal | ChemSusChem |
Volume | 12 |
Issue number | 13 |
DOIs | |
State | Published - Jul 5 2019 |
Keywords
- C−H activation
- homogeneous catalysis
- ligand effects
- organic synthesis
- transition metals