TY - JOUR
T1 - Trans-acting small interfering RNA4
T2 - Key to nutraceutical synthesis in grape development?
AU - Rock, Christopher D.
N1 - Funding Information:
The author thanks Blake Meyers and Pam Green for making publicly available sRNA datasets for 30 diverse plants including V. vinifera used in this analysis, Zhixin Xie, Matt Olson, Manoj Samanta, and Wendy Hood for helpful discussions, and the TTU High-Performance Computing Center for support of the Hrothgar computer cluster. This work was supported by the National Institutes of Health grant GM077245 to C.D.R.
PY - 2013/11
Y1 - 2013/11
N2 - The facility and versatility of microRNAs (miRNAs) to evolve and change likely underlies how they have become dominant constituents of eukaryotic genomes. In this opinion article I propose that trans-acting small interfering RNA gene 4 ( TAS4) evolution may be important for biosynthesis of polyphenolics, arbuscular symbiosis, and bacterial pathogen etiologies. Expression-based and phylogenetic evidence shows that TAS4 targets two novel grape ( Vitis vinifera L.) MYB transcription factors (VvMYBA6, VvMYBA7) that spawn phased small interfering RNAs (siRNAs) which probably function in nutraceutical bioflavonoid biosynthesis and fruit development. Characterization of the molecular mechanisms of TAS4 control of plant development and integration into biotic and abiotic stress- and nutrient-signaling regulatory networks has applicability to molecular breeding and the development of strategies for engineering healthier foods.
AB - The facility and versatility of microRNAs (miRNAs) to evolve and change likely underlies how they have become dominant constituents of eukaryotic genomes. In this opinion article I propose that trans-acting small interfering RNA gene 4 ( TAS4) evolution may be important for biosynthesis of polyphenolics, arbuscular symbiosis, and bacterial pathogen etiologies. Expression-based and phylogenetic evidence shows that TAS4 targets two novel grape ( Vitis vinifera L.) MYB transcription factors (VvMYBA6, VvMYBA7) that spawn phased small interfering RNAs (siRNAs) which probably function in nutraceutical bioflavonoid biosynthesis and fruit development. Characterization of the molecular mechanisms of TAS4 control of plant development and integration into biotic and abiotic stress- and nutrient-signaling regulatory networks has applicability to molecular breeding and the development of strategies for engineering healthier foods.
UR - http://www.scopus.com/inward/record.url?scp=84887025720&partnerID=8YFLogxK
U2 - 10.1016/j.tplants.2013.07.006
DO - 10.1016/j.tplants.2013.07.006
M3 - Review article
C2 - 23993483
AN - SCOPUS:84887025720
SN - 1360-1385
VL - 18
SP - 601
EP - 610
JO - Trends in Plant Science
JF - Trends in Plant Science
IS - 11
ER -