Abstract
TiCl4-Mediated Baylis-Hillman and aldol reactions were developed without the direct use of a Lewis base. These processes involve the conjugate addition of TiCl4 to α,β-unsaturated substrates followed by carbonyl coupling. Baylis-Hillman olefins were obtained when α,β-unsaturated ketones were employed as the substrates, whereas β-halogenated aldol products were generated with an α,β-unsaturated N-acyl benzoxalinone as the Michael-type acceptor.
Original language | English |
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Pages (from-to) | 1-5 |
Number of pages | 5 |
Journal | Tetrahedron Letters |
Volume | 41 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2000 |
Keywords
- Aldol reaction
- Baylis-Hillman reaction
- Titanium(IV) chloride