Abstract
α,β-Ethyl thioacrylate was difuctionalized by a tandem X-C/C=C bond formation reaction. The new system uses Ti (IV) halide as both the Lewis acidic promoter and the halogen source for the Michael-type addition onto the thioacrylate. The titanium enolate species resulting from Michael-type addition react with aldehydes followed by dehydration to afford trisubstituted olefin products. Complete geometric selectivity (>95%) and up to 72% yield have been obtained for 7 examples.
Original language | English |
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Pages (from-to) | 89-95 |
Number of pages | 7 |
Journal | Molecules |
Volume | 7 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2002 |
Keywords
- Aldol reaction
- Halide
- Thioester