Abstract
Efficient three-component domino strategies for the synthesis of multifunctionalized tetracyclic indeno[1,2-b]indole derivatives with different substituted patterns have been established successfully. The first pathway involves a novel sequential methyl migration, aromatization, and esterification, while a second reaction in HOAc leads to compounds 6 with high syn diastereoselectivity. Both reactions showed attractive features including mild conditions, convenient one-pot operation, short reaction times of 15-32 min, and excellent regio- and/or stereoselectivity.
Original language | English |
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Pages (from-to) | 5210-5213 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 20 |
DOIs | |
State | Published - Oct 19 2012 |