TY - JOUR
T1 - Three-Component Bicyclization Leading to Densely Functionalized
Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines
AU - Hao, Wen-Juan
AU - Zhou, Peng
AU - Wu, Fei-Yue
AU - Jiang, Bo
AU - Tu, Shu-Jiang
AU - Li, Guigen
PY - 2016/4
Y1 - 2016/4
N2 - A three-component bicyclization strategy for the efficient synthesis of
densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines
from readily accessible aryl aldehydes, -thiocyanate ketones, and
pyrazol-5-amines was established. The reaction pathway involves a
nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that
results in continuous multiple bond-forming events, including the
formation of C-N and C-C bonds, to give high levels of molecular
complexity.
AB - A three-component bicyclization strategy for the efficient synthesis of
densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines
from readily accessible aryl aldehydes, -thiocyanate ketones, and
pyrazol-5-amines was established. The reaction pathway involves a
nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that
results in continuous multiple bond-forming events, including the
formation of C-N and C-C bonds, to give high levels of molecular
complexity.
M3 - Article
SP - 1968
EP - 1971
JO - European Journal of Organic Chemistry
JF - European Journal of Organic Chemistry
ER -