Abstract
A three-component bicyclization strategy for the efficient synthesis of
densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines
from readily accessible aryl aldehydes, -thiocyanate ketones, and
pyrazol-5-amines was established. The reaction pathway involves a
nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that
results in continuous multiple bond-forming events, including the
formation of C-N and C-C bonds, to give high levels of molecular
complexity.
| Original language | English |
|---|---|
| Pages (from-to) | 1968-1971 |
| Journal | European Journal of Organic Chemistry |
| State | Published - Apr 2016 |