Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines

Wen-Juan Hao, Peng Zhou, Fei-Yue Wu, Bo Jiang, Shu-Jiang Tu, Guigen Li

Research output: Contribution to journalArticle


A three-component bicyclization strategy for the efficient synthesis of densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines from readily accessible aryl aldehydes, -thiocyanate ketones, and pyrazol-5-amines was established. The reaction pathway involves a nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that results in continuous multiple bond-forming events, including the formation of C-N and C-C bonds, to give high levels of molecular complexity.
Original languageEnglish
Pages (from-to)1968-1971
JournalEuropean Journal of Organic Chemistry
StatePublished - Apr 2016


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