@article{e9e7877ae0f84f168d0b9665e1302d95,
title = "Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines",
abstract = "A three-component bicyclization strategy for the efficient synthesis of densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines from readily accessible aryl aldehydes, α-thiocyanate ketones, and pyrazol-5-amines was established. The reaction pathway involves a nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that results in continuous multiple bond-forming events, including the formation of C-N and C-C bonds, to give high levels of molecular complexity.",
keywords = "Cyclization, Fused-ring systems, Microwave chemistry, Multicomponent reactions, Polycycles",
author = "Hao, {Wen Juan} and Peng Zhou and Wu, {Fei Yue} and Bo Jiang and Tu, {Shu Jiang} and Guigen Li",
note = "Funding Information: The authors are grateful for financial support from the National Natural Science Foundation of China (NSFC) (grant numbers 21332005, 21232004, and 21472071), Priority Academic Program Development of Jiangsu Higher Education Institutions, the Outstanding Youth Fund of Jiangsu Normal University (YQ2015003), National Science Foundation (NSF) of JiangsuProvince (BK20151163, 15KJB150006), Robert A. Welch Foundation (D-1361, USA), National Institutes of Health (NIH), USA (R33DA031860), and National Science Foundation of Jiangsu Normal University (14XLR005). Publisher Copyright: {\textcopyright} 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2016",
month = apr,
day = "1",
doi = "10.1002/ejoc.201600163",
language = "English",
volume = "2016",
pages = "1968--1971",
journal = "European Journal of Organic Chemistry",
issn = "1434-193X",
number = "11",
}