Abstract
A three-component bicyclization strategy for the efficient synthesis of densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines from readily accessible aryl aldehydes, α-thiocyanate ketones, and pyrazol-5-amines was established. The reaction pathway involves a nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that results in continuous multiple bond-forming events, including the formation of C-N and C-C bonds, to give high levels of molecular complexity.
Original language | English |
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Pages (from-to) | 1968-1971 |
Number of pages | 4 |
Journal | European Journal of Organic Chemistry |
Volume | 2016 |
Issue number | 11 |
DOIs | |
State | Published - Apr 1 2016 |
Keywords
- Cyclization
- Fused-ring systems
- Microwave chemistry
- Multicomponent reactions
- Polycycles