Three-Component Bicyclization Leading to Densely Functionalized Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines

Wen Juan Hao, Peng Zhou, Fei Yue Wu, Bo Jiang, Shu Jiang Tu, Guigen Li

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


A three-component bicyclization strategy for the efficient synthesis of densely functionalized pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidines from readily accessible aryl aldehydes, α-thiocyanate ketones, and pyrazol-5-amines was established. The reaction pathway involves a nucleophilic addition/5-exo-trig/6-endo-trig bicyclization sequence that results in continuous multiple bond-forming events, including the formation of C-N and C-C bonds, to give high levels of molecular complexity.

Original languageEnglish
Pages (from-to)1968-1971
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number11
StatePublished - Apr 1 2016


  • Cyclization
  • Fused-ring systems
  • Microwave chemistry
  • Multicomponent reactions
  • Polycycles


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