Thermo- and pH-responsive fluorescence behaviors of sulfur-functionalized detonation nanodiamond-poly(N-isopropylacrylamide)

Siheng Su, Junhua Wei, Kun Zhang, Jingjing Qiu, Shiren Wang

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Detonation nanodiamonds (DNDs) are emerging as bioimaging platforms due to their biocompability, small primary particle size, reactive surface, and stable fluorescence after modification. In this paper, a heteroatom engineering method is provided to fabricate the fluorescent DNDs through pyrolysis of dibenzyl disulfide. The quantum yield of these sulfur (S)-functionalized DNDs (SDNDs) increases with sulfur percentage. The solubility and stability of SDNDs in aqueous solution are also significantly increased due to the formation of hydrophilic sulfur groups on DND. Furthermore, these SDNDs are used to conjugate the stimuli-responsive poly(N-isopropylacrylamide) (PNIPAM) through the ‘graft from’ method. The conjugation demonstrated both pH- and thermo-responsive fluorescence behaviors, which shows promise to be used in ratiometric fluorescence sensing for the detection of intracellular pH and temperature values.

Original languageEnglish
Pages (from-to)1299-1305
Number of pages7
JournalColloid and Polymer Science
Issue number4
StatePublished - Apr 1 2015


  • Nanodiamond
  • Poly(N-isopropylacrylamide)
  • Thermo-responsive
  • pH-responsive


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