The tricuspid valve also maladapts as shown in sheep with biventricular heart failure

William D. Meador, Mrudang Mathur, Gabriella P. Sugerman, Marcin Malinowski, Tomasz Jazwiec, Xinmei Wang, Carla Mr Lacerda, Tomasz A. Timek, Manuel K. Rausch

Research output: Contribution to journalArticlepeer-review


Over 1.6 million Americans suffer from significant tricuspid valve leakage. In most cases this leakage is designated as secondary. Thus, valve dysfunction is assumed to be due to valve-extrinsic factors. We challenge this paradigm and hypothesize that the tricuspid valve maladapts in those patients rendering the valve at least partially culpable for its dysfunction. As a first step in testing this hypothesis, we set out to demonstrate that the tricuspid valve maladapts in disease. To this end, we induced biventricular heart failure in sheep that developed tricuspid valve leakage. In the anterior leaflets of those animals, we investigated maladaptation on multiple scales. We demonstrated alterations on the protein and cell-level, leading to tissue growth, thickening, and stiffening. These data provide a new perspective on a poorly understood, yet highly prevalent disease. Our findings may motivate novel therapy options for many currently untreated patients with leaky tricuspid valves.

Original languageEnglish
Article numbere63855
Pages (from-to)1-22
Number of pages22
StatePublished - Dec 2020


Dive into the research topics of 'The tricuspid valve also maladapts as shown in sheep with biventricular heart failure'. Together they form a unique fingerprint.

Cite this