@article{87109456d0bb4c0c90422112ed16a9fc,
title = "The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet",
abstract = "The prevention or delay of the onset of age-related diseases prolongs survival and improves quality of life while reducing the burden on the health care system. Activation of sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, improves metabolism and confers protection against physiological and cognitive disturbances inold age. SRT1720 is a specific SIRT1 activator that has health and lifespan benefits in adult mice fed ahigh-fat diet. We found extension in lifespan, delayedonset of age-related metabolic diseases, and improved general health in mice fed a standard diet after SRT1720 supplementation. Inhibition of proinflammatory gene expression in both liver and muscle of SRT1720-treated animals was noted. SRT1720 lowered the phosphorylation of NF-κB pathway regulators invitro only when SIRT1 was functionally present. Combined with our previous work, the current study further supports the beneficial effects of SRT1720 on health across the lifespan in mice.",
author = "Mitchell, {Sarah J.} and Alejandro Martin-Montalvo and Mercken, {Evi M.} and Palacios, {Hector H.} and Ward, {Theresa M.} and Gelareh Abulwerdi and Minor, {Robin K.} and Vlasuk, {George P.} and Ellis, {James L.} and Sinclair, {David A.} and John Dawson and Allison, {David B.} and Yongqing Zhang and Becker, {Kevin G.} and Michel Bernier and {De Cabo}, Rafael",
note = "Funding Information: This research was conducted under a Cooperative Research and Development Agreement (CRADA) between Sirtris, a GSK Company, and the National Institute on Aging, National Institutes of Health (NIA/NIH). Funding was provided by the Intramural Research Program of the NIA/NIH. We are grateful to Dawn Nines, Justine Lucas, and Dawn Phillips-Boyer for their excellent animal care. We thank Dr. Elin Lehrmann for microarray assistance. We thank Drs. Hua-Jun He (National Institute of Standards and Technology, Gaithersburg, MD), Yaping Zong (Full Moon Biosystems, Inc., Sunnyvale, CA), and Xiong Li (Department of Mathematics and Computer Science, Emory University, Atlanta, GA) for their contribution in carrying out the phosphoantibody array experiment and data analysis. We thank Dr. Norm Wolf for the assessment of cataracts in the mice and Olga Carlson for technical assistance with the multiplex assay. S.J.M. was supported by a National Medical Health and Research Council of Australia CJ Martin Early Career Fellowship (RGMS ID 2010-01671). J.D. is supported by a University of Alabama at Birmingham Statistical Genetics Postdoctoral Training Program Grant (T32HL072757). D.A.S. consults for and G.P.V. and J.L.E. are employed by Sirtris, a GSK Company that has a commercial interest in developing SIRT1 activators. ",
year = "2014",
doi = "10.1016/j.celrep.2014.01.031",
language = "English",
volume = "6",
pages = "836--843",
journal = "Cell Reports",
issn = "2211-1247",
number = "5",
}