The role of somatostatins in the regulation of metabolism in fish

Mark A. Sheridan, Jeffrey D. Kittilson

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Somatostatins (SS) are a structurally and functionally diverse family of peptide hormones. Somatostatins possess a wide variety of biological functions, including numerous secretotropic, developmental, and metabolic effects. Studies on fish have revealed considerable insight into the role of SS on the regulation of intermediary metabolism. Somatostatins promote both lipid and carbohydrate breakdown in fish and lamprey. Such actions are mediated by secretotropic effects of SS. For example, SS inhibit insulin (INS); insulin deficiency favors lipolysis and glycogenolysis over lipogenesis and glycogenesis. Somatostatins also directly stimulate the breakdown of stored triacylglycerols (TG) and glycogen in storage tissues. In addition, SS interact with the growth and reproductive axes of fish, findings that suggest SS serve to modulate energy partitioning among various growth, development and reproductive processes.

Original languageEnglish
Pages (from-to)323-330
Number of pages8
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Issue number4
StatePublished - Aug 2004


  • Fish
  • Metabolism
  • Somatostatins


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