TY - JOUR
T1 - The role of somatostatins in the regulation of metabolism in fish
AU - Sheridan, Mark A.
AU - Kittilson, Jeffrey D.
N1 - Funding Information:
We are extremely grateful to our past and current collaborators for their contributions to this work. Some of the research presented in this paper was supported by grants from the National Science Foundation (IBN 0076416) and the US Department of Agriculture (NRICGP 98-35206-6410) to MAS. We also would like to thank Brendan Kelly, Laura Nelson, Nicole Very, and Nathan Wiederholt for their assistance with the preparation of the manuscript. This paper is dedicated to Prof. William V. Allen (Humboldt State University), who introduced one of us (MAS) to the process of science and to the study of metabolism.
PY - 2004/8
Y1 - 2004/8
N2 - Somatostatins (SS) are a structurally and functionally diverse family of peptide hormones. Somatostatins possess a wide variety of biological functions, including numerous secretotropic, developmental, and metabolic effects. Studies on fish have revealed considerable insight into the role of SS on the regulation of intermediary metabolism. Somatostatins promote both lipid and carbohydrate breakdown in fish and lamprey. Such actions are mediated by secretotropic effects of SS. For example, SS inhibit insulin (INS); insulin deficiency favors lipolysis and glycogenolysis over lipogenesis and glycogenesis. Somatostatins also directly stimulate the breakdown of stored triacylglycerols (TG) and glycogen in storage tissues. In addition, SS interact with the growth and reproductive axes of fish, findings that suggest SS serve to modulate energy partitioning among various growth, development and reproductive processes.
AB - Somatostatins (SS) are a structurally and functionally diverse family of peptide hormones. Somatostatins possess a wide variety of biological functions, including numerous secretotropic, developmental, and metabolic effects. Studies on fish have revealed considerable insight into the role of SS on the regulation of intermediary metabolism. Somatostatins promote both lipid and carbohydrate breakdown in fish and lamprey. Such actions are mediated by secretotropic effects of SS. For example, SS inhibit insulin (INS); insulin deficiency favors lipolysis and glycogenolysis over lipogenesis and glycogenesis. Somatostatins also directly stimulate the breakdown of stored triacylglycerols (TG) and glycogen in storage tissues. In addition, SS interact with the growth and reproductive axes of fish, findings that suggest SS serve to modulate energy partitioning among various growth, development and reproductive processes.
KW - Fish
KW - Metabolism
KW - Somatostatins
UR - http://www.scopus.com/inward/record.url?scp=4344591433&partnerID=8YFLogxK
U2 - 10.1016/j.cbpc.2004.04.006
DO - 10.1016/j.cbpc.2004.04.006
M3 - Review article
C2 - 15325331
AN - SCOPUS:4344591433
SN - 1096-4959
VL - 138
SP - 323
EP - 330
JO - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
JF - Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
IS - 4
ER -