TY - JOUR
T1 - The other white-nose syndrome transcriptome: tolerant and suscetible hosts respond differently to infection with Pseudogymnoascus destructans
AU - Davy, Christina M
AU - Donaldson, Michael E
AU - Willis, Craig KR
AU - Saville, Barry J
AU - McGuire, Liam
AU - Mayberry, Heather
AU - Wilcox, Alana
AU - Wibbelt, Gudrun
AU - Misra, Vikram
AU - Bollinger, Trent
AU - Kyle, Christopher J
PY - 2017/8/2
Y1 - 2017/8/2
N2 - Mitigation of emerging infectious diseases that threaten global biodiversity requires an understanding of critical host and pathogen responses to infection. For multihost pathogens where pathogen virulence or host susceptibility is variable, host–pathogen interactions in tolerant species may identify potential avenues for adaptive evolution in recently exposed, susceptible hosts. For example, the fungus Pseudogymnoascus destructans causes white‐nose syndrome (WNS) in hibernating bats and is responsible for catastrophic declines in some species in North America, where it was recently introduced. Bats in Europe and Asia, where the pathogen is endemic, are only mildly affected. Different environmental conditions among Nearctic and Palearctic hibernacula have been proposed as an explanation for variable disease outcomes, but this hypothesis has not been experimentally tested. We report the first controlled, experimental investigation of response to P. destructans in a tolerant, European s
AB - Mitigation of emerging infectious diseases that threaten global biodiversity requires an understanding of critical host and pathogen responses to infection. For multihost pathogens where pathogen virulence or host susceptibility is variable, host–pathogen interactions in tolerant species may identify potential avenues for adaptive evolution in recently exposed, susceptible hosts. For example, the fungus Pseudogymnoascus destructans causes white‐nose syndrome (WNS) in hibernating bats and is responsible for catastrophic declines in some species in North America, where it was recently introduced. Bats in Europe and Asia, where the pathogen is endemic, are only mildly affected. Different environmental conditions among Nearctic and Palearctic hibernacula have been proposed as an explanation for variable disease outcomes, but this hypothesis has not been experimentally tested. We report the first controlled, experimental investigation of response to P. destructans in a tolerant, European s
U2 - 10.1002/ece3.3234/full
DO - 10.1002/ece3.3234/full
M3 - Article
SP - 7161
EP - 7170
JO - Ecology and Evolution
JF - Ecology and Evolution
ER -