The impact of intraspecies and interspecies bacterial interactions on disease outcome

Jiwasmika Baishya, Karishma Bisht, Jeanette N. Rimbey, Kiddist D. Yihunie, Shariful Islam, Hafij Al Mahmud, Jayc E. Waller, Catherine A. Wakeman

Research output: Contribution to journalReview articlepeer-review

Abstract

The human microbiota is an array of microorganisms known to interact with the host and other microbes. These interactions can be competitive, as microbes must adapt to host-and microorganism-related stressors, thus producing toxic molecules, or cooperative, whereby microbes survive by maintaining homeostasis with the host and host-associated microbial communities. As a result, these microbial interactions shape host health and can potentially result in disease. In this review, we discuss these varying interactions across microbial species, their positive and negative effects, the therapeutic potential of these interactions, and their implications on our knowledge of human well-being.

Original languageEnglish
Article number96
Pages (from-to)1-11
Number of pages11
JournalPathogens
Volume10
Issue number2
DOIs
StatePublished - Feb 2021

Keywords

  • Bacterial interactions
  • Commensal
  • Host–pathogen interface
  • Pathogen
  • Polymicrobial infection

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