The end of Nef's tether

Ruth Serra-Moreno

Research output: Contribution to journalShort surveypeer-review

1 Scopus citations


Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.

Original languageEnglish
Pages (from-to)662-664
Number of pages3
JournalTrends in Microbiology
Issue number12
StatePublished - Dec 1 2014


  • HIV
  • Nef
  • Restriction
  • Tetherin

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