The end of Nef's tether

Ruth Serra-Moreno

doi:10.1016/j.tim.2014.10.008

The end of Nef's tether

Ruth Serra-Moreno

Biological Sciences

Research output: Contribution to journal › Short survey › peer-review

1 Scopus citations

Abstract

Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.

Original language	English
Pages (from-to)	662-664
Number of pages	3
Journal	Trends in Microbiology
Volume	22
Issue number	12
DOIs	https://doi.org/10.1016/j.tim.2014.10.008
State	Published - Dec 1 2014

Keywords

HIV
Nef
Restriction
Tetherin

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10.1016/j.tim.2014.10.008

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title = "The end of Nef's tether",

abstract = "Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.",

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N2 - Tetherin represents an important barrier for successful cross-species transmissions of primate lentiviruses. HIV-1 overcame this obstacle by using Vpu as a countermeasure. However, Kluge and collaborators now show that HIV-1 group O uses Nef to antagonize tetherin, and that this activity may have contributed to its spread in West-Central Africa.

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KW - Nef

KW - Restriction

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M3 - Short survey

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JO - Trends in Microbiology

JF - Trends in Microbiology

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The end of Nef's tether

Abstract

Keywords

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