The effect of nanoclays on nanofiber density gradient in 3D scaffolds fabricated by divergence electrospinning

Yingge Zhou, Shahrima Mahurubin, Dilshan Sooriyaarachchi, George Z. Tan

Research output: Contribution to journalConference article

Abstract

Tissue engineering generally requires the use of artificial scaffolds to recreating the in vivo milieu which coordinates complex spatiotemporal mechanisms to guide cell behavior. Studies showed that aligned nanofiber scaffolds provide biophysical stimuli to promote cell adhesion, proliferation, morphogenesis, and motility. This study presents a 3D assembly process of aligned polycaprolactone nanofibers directed by a symmetrically divergent electric field. Nanoclays (phyllosilicate) were added into the polymer solution to enhance the homogeneity of fiber distribution within the scaffold. The conductivity and viscosity of solutions were characterized. The nanofiber attributes including fiber diameter, fiber density, and fiber alignment were analyzed by scanning electron microscopy. The results showed that the homogeneity of nanofiber distribution with regard to density and alignment were positively correlated with the conductivity and viscosity of polymer solution. This study demonstrated the feasibility of fine-tuning the microstructure of 3D assembled nanofiber scaffolds by altering the material properties.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalProcedia Manufacturing
Volume34
DOIs
StatePublished - Jan 1 2019
Event47th SME North American Manufacturing Research Conference, NAMRC 2019 - Erie, United States
Duration: Jun 10 2019Jun 14 2019

    Fingerprint

Keywords

  • Directed assembly
  • Divergence electrospinning
  • Nanoclay
  • Nanofiber scaffold
  • Tissue engineering

Cite this