The D3 science-to-design methodology: Automated and cognitive-based processes for discovering, describing, and designing complex nanomechanical biosystems

Paul Egan; Jonathan Cagan; Christian Schunn; Philip LeDuc; Jeffrey Moore; Felix Chiu

doi:10.1115/DETC201547466

The D3 science-to-design methodology: Automated and cognitive-based processes for discovering, describing, and designing complex nanomechanical biosystems

Paul Egan, Jonathan Cagan, Christian Schunn, Philip LeDuc, Jeffrey Moore, Felix Chiu

Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

New opportunities in design often surface with scientific advances, however, the rapid pace of scientific findings in biological domains, and their complexity, may impede effective technological design. This paper addresses such challenges through weaving phases of scientific discovery, analytical description, and technological design in an integrative "d3 Methodology." The method is implemented using human-guided automated processes developed with cognitive-based considerations. A case study of designing myosin bio-libraries is specifically investigated, and optimization results suggest that biolibraries of designed synthetic isoforms have advantages over natural isoforms. The findings are motivating for future scientific endeavors to investigate the benefits of designed myosins, thus demonstrating reciprocity among design and science. The successes in implementing each d3 phase suggests the methodology is a feasible approach for nanoscale biosystems design, and is well-suited for driving the scientific inquiries of today towards the novel technologies of tomorrow.

Original language	English
Title of host publication	27th International Conference on Design Theory and Methodology
Publisher	American Society of Mechanical Engineers (ASME)
ISBN (Electronic)	9780791857175
DOIs	https://doi.org/10.1115/DETC201547466
State	Published - 2015
Event	ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015 - Boston, United States Duration: Aug 2 2015 → Aug 5 2015

Publication series

Name	Proceedings of the ASME Design Engineering Technical Conference
Volume	7

Conference

Conference	ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015
Country	United States
City	Boston
Period	08/2/15 → 08/5/15

Access to Document

10.1115/DETC201547466

Link to publication in Scopus

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Egan, P., Cagan, J., Schunn, C., LeDuc, P., Moore, J., & Chiu, F. (2015). The D3 science-to-design methodology: Automated and cognitive-based processes for discovering, describing, and designing complex nanomechanical biosystems. In 27th International Conference on Design Theory and Methodology (Proceedings of the ASME Design Engineering Technical Conference; Vol. 7). American Society of Mechanical Engineers (ASME). https://doi.org/10.1115/DETC201547466

Egan, Paul ; Cagan, Jonathan ; Schunn, Christian ; LeDuc, Philip ; Moore, Jeffrey ; Chiu, Felix. / The D3 science-to-design methodology : Automated and cognitive-based processes for discovering, describing, and designing complex nanomechanical biosystems. 27th International Conference on Design Theory and Methodology. American Society of Mechanical Engineers (ASME), 2015. (Proceedings of the ASME Design Engineering Technical Conference).

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Egan, P, Cagan, J, Schunn, C, LeDuc, P, Moore, J & Chiu, F 2015, The D3 science-to-design methodology: Automated and cognitive-based processes for discovering, describing, and designing complex nanomechanical biosystems. in 27th International Conference on Design Theory and Methodology. Proceedings of the ASME Design Engineering Technical Conference, vol. 7, American Society of Mechanical Engineers (ASME), ASME 2015 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference, IDETC/CIE 2015, Boston, United States, 08/2/15. https://doi.org/10.1115/DETC201547466

The D3 science-to-design methodology : Automated and cognitive-based processes for discovering, describing, and designing complex nanomechanical biosystems. / Egan, Paul; Cagan, Jonathan; Schunn, Christian; LeDuc, Philip; Moore, Jeffrey; Chiu, Felix.

27th International Conference on Design Theory and Methodology. American Society of Mechanical Engineers (ASME), 2015. (Proceedings of the ASME Design Engineering Technical Conference; Vol. 7).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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Egan P, Cagan J, Schunn C, LeDuc P, Moore J, Chiu F. The D3 science-to-design methodology: Automated and cognitive-based processes for discovering, describing, and designing complex nanomechanical biosystems. In 27th International Conference on Design Theory and Methodology. American Society of Mechanical Engineers (ASME). 2015. (Proceedings of the ASME Design Engineering Technical Conference). https://doi.org/10.1115/DETC201547466