TY - GEN
T1 - The D3 science-to-design methodology
AU - Egan, Paul
AU - Cagan, Jonathan
AU - Schunn, Christian
AU - LeDuc, Philip
AU - Moore, Jeffrey
AU - Chiu, Felix
N1 - Publisher Copyright:
Copyright © 2015 by ASME.
PY - 2015
Y1 - 2015
N2 - New opportunities in design often surface with scientific advances, however, the rapid pace of scientific findings in biological domains, and their complexity, may impede effective technological design. This paper addresses such challenges through weaving phases of scientific discovery, analytical description, and technological design in an integrative "d3 Methodology." The method is implemented using human-guided automated processes developed with cognitive-based considerations. A case study of designing myosin bio-libraries is specifically investigated, and optimization results suggest that biolibraries of designed synthetic isoforms have advantages over natural isoforms. The findings are motivating for future scientific endeavors to investigate the benefits of designed myosins, thus demonstrating reciprocity among design and science. The successes in implementing each d3 phase suggests the methodology is a feasible approach for nanoscale biosystems design, and is well-suited for driving the scientific inquiries of today towards the novel technologies of tomorrow.
AB - New opportunities in design often surface with scientific advances, however, the rapid pace of scientific findings in biological domains, and their complexity, may impede effective technological design. This paper addresses such challenges through weaving phases of scientific discovery, analytical description, and technological design in an integrative "d3 Methodology." The method is implemented using human-guided automated processes developed with cognitive-based considerations. A case study of designing myosin bio-libraries is specifically investigated, and optimization results suggest that biolibraries of designed synthetic isoforms have advantages over natural isoforms. The findings are motivating for future scientific endeavors to investigate the benefits of designed myosins, thus demonstrating reciprocity among design and science. The successes in implementing each d3 phase suggests the methodology is a feasible approach for nanoscale biosystems design, and is well-suited for driving the scientific inquiries of today towards the novel technologies of tomorrow.
UR - http://www.scopus.com/inward/record.url?scp=84979020627&partnerID=8YFLogxK
U2 - 10.1115/DETC201547466
DO - 10.1115/DETC201547466
M3 - Conference contribution
AN - SCOPUS:84979020627
T3 - Proceedings of the ASME Design Engineering Technical Conference
BT - 27th International Conference on Design Theory and Methodology
PB - American Society of Mechanical Engineers (ASME)
Y2 - 2 August 2015 through 5 August 2015
ER -