TY - JOUR
T1 - The D3 Methodology
T2 - Bridging Science and Design for Bio-Based Product Development
AU - Egan, Paul
AU - Cagan, Jonathan
AU - Schunn, Christian
AU - Chiu, Felix
AU - Moore, Jeffrey
AU - LeDuc, Philip
N1 - Funding Information:
Funding support was provided by the National Defense Science and Engineering Fellowship and the National Science Foundation under Grant No. CMMI-1160840.
Publisher Copyright:
© 2016 by ASME.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - New opportunities in design surface with scientific advances: however, the rapid pace of scientific discoveries combined with the complexity of technical barriers often impedes new product development. Bio-based technologies, for instance, typically require decisions across complex multiscale system organizations that are difficult for humans to understand and formalize computationally. This paper addresses such challenges in science and design by weaving phases of empirical discovery, analytical description, and technological development in an integrative "D3 Methodology." The phases are bridged with human-guided computational processes suitable for human-in-the-loop design approaches. Optimization of biolibraries, which are sets of standardized biological parts for adaptation into new products, is used as a characteristic design problem for demonstrating the methodology. Results from this test case suggest that biolibraries with synthetic biological components can promote the development of high-performance bio-based products. These new products motivate further scientific studies to characterize designed synthetic biological components, thus illustrating reciprocity among science and design. Successes in implementing each phase suggest the D3 Methodology is a feasible route for bio-based research and development and for driving the scientific inquiries of today toward the novel technologies of tomorrow.
AB - New opportunities in design surface with scientific advances: however, the rapid pace of scientific discoveries combined with the complexity of technical barriers often impedes new product development. Bio-based technologies, for instance, typically require decisions across complex multiscale system organizations that are difficult for humans to understand and formalize computationally. This paper addresses such challenges in science and design by weaving phases of empirical discovery, analytical description, and technological development in an integrative "D3 Methodology." The phases are bridged with human-guided computational processes suitable for human-in-the-loop design approaches. Optimization of biolibraries, which are sets of standardized biological parts for adaptation into new products, is used as a characteristic design problem for demonstrating the methodology. Results from this test case suggest that biolibraries with synthetic biological components can promote the development of high-performance bio-based products. These new products motivate further scientific studies to characterize designed synthetic biological components, thus illustrating reciprocity among science and design. Successes in implementing each phase suggest the D3 Methodology is a feasible route for bio-based research and development and for driving the scientific inquiries of today toward the novel technologies of tomorrow.
UR - http://www.scopus.com/inward/record.url?scp=84975292866&partnerID=8YFLogxK
U2 - 10.1115/1.4033751
DO - 10.1115/1.4033751
M3 - Article
AN - SCOPUS:84975292866
VL - 138
JO - Journal of Mechanical Design, Transactions of the ASME
JF - Journal of Mechanical Design, Transactions of the ASME
SN - 1050-0472
IS - 8
M1 - 081101
ER -