Abstract
The first application of trans-alkyl cinnamate-based aminohalogenation to the synthesis of anti methyl 3-aryl-N-(p-toluene)sulfonylaziridine-2- carboxylates and anti methyl 3-aryl-N-(o-nitrobenzene)sulfonylaziridine-2- carboxylates was described. The synthesis was easily carried out by mixing alkyl cinnamate-derived haloamines with potassium carbonate in acetonitrile at room temperature. Good to excellent yields (83-97% for N-p-Ts and 75-94% for N-o-Ns trans-aziridine-2-carboxylates, respectively) have been achieved for 11 examples.
Original language | English |
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Pages (from-to) | 56-62 |
Number of pages | 7 |
Journal | Arkivoc |
Volume | 2003 |
Issue number | 12 |
State | Published - 2003 |
Keywords
- Aminohalogenation
- Aziridine
- Cinnamate
- Haloamine