The asymmetric catalytic aldol reaction of allenolates with aldehydes using N-fluoroacyl oxazaborolidine as the catalyst

Guigen Li, Han Xun Wei, Brian S. Phelps, David W. Purkiss, Sun Hee Kim

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

matrix presented The asymmetric catalytic aldol reaction of silyl allenolates with aldehydes has been achieved by using N-C3F7CO oxazaborolidine as the catalyst. The fluoroacyl group of the catalyst was found to be crucial for control of enantioselectivity. The reaction provides the first enantioselective approach to β-halo Baylis-Hillman-type adducts.

Original languageEnglish
Pages (from-to)823-826
Number of pages4
JournalOrganic Letters
Volume3
Issue number6
DOIs
StatePublished - Mar 22 2001

Fingerprint

Dive into the research topics of 'The asymmetric catalytic aldol reaction of allenolates with aldehydes using N-fluoroacyl oxazaborolidine as the catalyst'. Together they form a unique fingerprint.

Cite this