The art of microRNA: Various strategies leading to gene silencing via an ancient pathway

Guiliang Tang; Xiaoqing Tang; Venugopal Mendu; Xiaohu Tang; Xiaoyun Jia; Qi Jun Chen; Liheng He

doi:10.1016/j.bbagrm.2008.06.006

The art of microRNA: Various strategies leading to gene silencing via an ancient pathway

Guiliang Tang, Xiaoqing Tang, Venugopal Mendu, Xiaohu Tang, Xiaoyun Jia, Qi Jun Chen, Liheng He

Research output: Contribution to journal › Review article › peer-review

45 Scopus citations

Abstract

MicroRNAs (miRNAs), an endogenous type of small RNAs of ∼ 22 nucleotides (nt), have long resided in the cells of plants and animals including humans, constituting an ancient pathway of gene regulation in eukaryotes. They have a simple structure in their mature form but carry enormous information that may regulate up to 90% of the human transcriptome. Furthermore, the multi-facets of a miRNA are tightly associated with diverse cellular proteins that make it broadly connected to various physiological and pathological processes. This review aims to examine miRNAs briefly from their biogenesis to their general functions with an emphasis on working mechanisms in regulation of their target mRNAs.

Original language	English
Pages (from-to)	655-662
Number of pages	8
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1779
Issue number	11
DOIs	https://doi.org/10.1016/j.bbagrm.2008.06.006
State	Published - Nov 2008

Keywords

RISC
Target cleavage
Translational repression
miRNA

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10.1016/j.bbagrm.2008.06.006

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title = "The art of microRNA: Various strategies leading to gene silencing via an ancient pathway",

abstract = "MicroRNAs (miRNAs), an endogenous type of small RNAs of ∼ 22 nucleotides (nt), have long resided in the cells of plants and animals including humans, constituting an ancient pathway of gene regulation in eukaryotes. They have a simple structure in their mature form but carry enormous information that may regulate up to 90% of the human transcriptome. Furthermore, the multi-facets of a miRNA are tightly associated with diverse cellular proteins that make it broadly connected to various physiological and pathological processes. This review aims to examine miRNAs briefly from their biogenesis to their general functions with an emphasis on working mechanisms in regulation of their target mRNAs.",

keywords = "RISC, Target cleavage, Translational repression, miRNA",

author = "Guiliang Tang and Xiaoqing Tang and Venugopal Mendu and Xiaohu Tang and Xiaoyun Jia and Chen, {Qi Jun} and Liheng He",

note = "Funding Information: Particular thanks to Dr. Phil Zamore for the email discussion of specific issues during the preparation of this article and thanks also to several anonymous reviewers for their constructive comments and suggestions. G.T. is supported by the Kentucky Tobacco Research and Development Center (KTRDC), the USDA-NRI grants 2006-35301-17115 and 2006-35100-17433, the NSF MCB-0718029 (Subaward No. S-00000260), the NIH 5 R03 AI 068934-02, and an award from the Kentucky Science and Technology Corporation under Contract # KSTC-144-401-08-029.",

year = "2008",

month = nov,

doi = "10.1016/j.bbagrm.2008.06.006",

language = "English",

volume = "1779",

pages = "655--662",

journal = "Biochimica et Biophysica Acta - Gene Regulatory Mechanisms",

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T2 - Various strategies leading to gene silencing via an ancient pathway

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AU - Tang, Xiaoqing

AU - Mendu, Venugopal

AU - Tang, Xiaohu

AU - Jia, Xiaoyun

AU - Chen, Qi Jun

AU - He, Liheng

N1 - Funding Information: Particular thanks to Dr. Phil Zamore for the email discussion of specific issues during the preparation of this article and thanks also to several anonymous reviewers for their constructive comments and suggestions. G.T. is supported by the Kentucky Tobacco Research and Development Center (KTRDC), the USDA-NRI grants 2006-35301-17115 and 2006-35100-17433, the NSF MCB-0718029 (Subaward No. S-00000260), the NIH 5 R03 AI 068934-02, and an award from the Kentucky Science and Technology Corporation under Contract # KSTC-144-401-08-029.

PY - 2008/11

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N2 - MicroRNAs (miRNAs), an endogenous type of small RNAs of ∼ 22 nucleotides (nt), have long resided in the cells of plants and animals including humans, constituting an ancient pathway of gene regulation in eukaryotes. They have a simple structure in their mature form but carry enormous information that may regulate up to 90% of the human transcriptome. Furthermore, the multi-facets of a miRNA are tightly associated with diverse cellular proteins that make it broadly connected to various physiological and pathological processes. This review aims to examine miRNAs briefly from their biogenesis to their general functions with an emphasis on working mechanisms in regulation of their target mRNAs.

AB - MicroRNAs (miRNAs), an endogenous type of small RNAs of ∼ 22 nucleotides (nt), have long resided in the cells of plants and animals including humans, constituting an ancient pathway of gene regulation in eukaryotes. They have a simple structure in their mature form but carry enormous information that may regulate up to 90% of the human transcriptome. Furthermore, the multi-facets of a miRNA are tightly associated with diverse cellular proteins that make it broadly connected to various physiological and pathological processes. This review aims to examine miRNAs briefly from their biogenesis to their general functions with an emphasis on working mechanisms in regulation of their target mRNAs.

KW - RISC

KW - Target cleavage

KW - Translational repression

KW - miRNA

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IS - 11

ER -

The art of microRNA: Various strategies leading to gene silencing via an ancient pathway

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Keywords

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