The antiaggressive effect of lithium is abolished by area postrema lesion

John J. McGlone, Sue Ritter, Keith W. Kelley

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Lithium (Li) suppresses intraspecific aggression in rats and other mammals. However, antiaggressive doses of Li have been shown to produce signs of illness and to serve as an unconditioned stimulus for conditioned taste aversions (CTA). Therefore, it is possible that the antiaggressive effects of Li result from Li-induced malaise. Malaise and CTA's produced by some drugs and toxins are mediated by chemoreceptors in the area postrema. In this paper we report [1] that thermal lesion of the area postrema abolishes Li's ability to condition taste aversions and [2] that area postrema lesion abolishes the antiaggressive effect of Li as measured by attack latency in a shock-induced aggression test. Taken together, these findings suggest that some or all of Li's antiaggressive action in rats may result from malaise attributable to Li's action on the area postrema.

Original languageEnglish
Pages (from-to)1095-1100
Number of pages6
JournalPhysiology and Behavior
Volume24
Issue number6
DOIs
StatePublished - Jun 1980

Keywords

  • Area postrema lesion
  • Conditioned taste aversion
  • Lithium chloride
  • Malaise
  • Shock-induced aggression

Fingerprint Dive into the research topics of 'The antiaggressive effect of lithium is abolished by area postrema lesion'. Together they form a unique fingerprint.

  • Cite this