The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet Rich Plasma in Osteoarthritis

Emily Sundman; Brian Cole; V Karas; C Della Valle; M Tetrault; H Mohammed; Lisa Fortier

The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet Rich Plasma in Osteoarthritis

Emily Sundman, Brian Cole, V Karas, C Della Valle, M Tetrault, H Mohammed, Lisa Fortier

Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis (OA) results in improved patient-reported pain and function scores. Purpose: To measure the effects of PRP and high molecular weight hyaluronan (HA) on the expression of anabolic and catabolic genes and on the secretion of nociceptive and inflammatory mediators from OA cartilage and synoviocytes. Study design: Controlled laboratory study. Methods: Synovium and cartilage harvested from patients undergoing total knee arthroplasty were co-cultured with media of PRP or HA. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β were measured in the media by enzyme-linked immunosorbent assay. Hyaluronan synthase-2 (HAS-2), matrix metalloproteina

Original language	English
Pages (from-to)	35-41
Journal	American Journal of Sports Medicine
State	Published - Jan 2014

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title = "The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet Rich Plasma in Osteoarthritis",

abstract = "Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis (OA) results in improved patient-reported pain and function scores. Purpose: To measure the effects of PRP and high molecular weight hyaluronan (HA) on the expression of anabolic and catabolic genes and on the secretion of nociceptive and inflammatory mediators from OA cartilage and synoviocytes. Study design: Controlled laboratory study. Methods: Synovium and cartilage harvested from patients undergoing total knee arthroplasty were co-cultured with media of PRP or HA. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β were measured in the media by enzyme-linked immunosorbent assay. Hyaluronan synthase-2 (HAS-2), matrix metalloproteina",

author = "Emily Sundman and Brian Cole and V Karas and Valle, {C Della} and M Tetrault and H Mohammed and Lisa Fortier",

year = "2014",

month = jan,

language = "English",

pages = "35--41",

journal = "American Journal of Sports Medicine",

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TY - JOUR

T1 - The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet Rich Plasma in Osteoarthritis

AU - Sundman, Emily

AU - Cole, Brian

AU - Karas, V

AU - Valle, C Della

AU - Tetrault, M

AU - Mohammed, H

AU - Fortier, Lisa

PY - 2014/1

Y1 - 2014/1

N2 - Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis (OA) results in improved patient-reported pain and function scores. Purpose: To measure the effects of PRP and high molecular weight hyaluronan (HA) on the expression of anabolic and catabolic genes and on the secretion of nociceptive and inflammatory mediators from OA cartilage and synoviocytes. Study design: Controlled laboratory study. Methods: Synovium and cartilage harvested from patients undergoing total knee arthroplasty were co-cultured with media of PRP or HA. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β were measured in the media by enzyme-linked immunosorbent assay. Hyaluronan synthase-2 (HAS-2), matrix metalloproteina

AB - Background: Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis (OA) results in improved patient-reported pain and function scores. Purpose: To measure the effects of PRP and high molecular weight hyaluronan (HA) on the expression of anabolic and catabolic genes and on the secretion of nociceptive and inflammatory mediators from OA cartilage and synoviocytes. Study design: Controlled laboratory study. Methods: Synovium and cartilage harvested from patients undergoing total knee arthroplasty were co-cultured with media of PRP or HA. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β were measured in the media by enzyme-linked immunosorbent assay. Hyaluronan synthase-2 (HAS-2), matrix metalloproteina

M3 - Article

SP - 35

EP - 41

JO - American Journal of Sports Medicine

JF - American Journal of Sports Medicine

ER -

The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet Rich Plasma in Osteoarthritis

Abstract

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