The Anti-inflammatory and Matrix Restorative Mechanisms of Platelet Rich Plasma in Osteoarthritis

Emily Sundman, Brian Cole, V Karas, C Della Valle, M Tetrault, H Mohammed, Lisa Fortier

Research output: Contribution to journalArticlepeer-review

Abstract

<b>Background:</b> Intra-articular (IA) treatment with platelet-rich plasma (PRP) for osteoarthritis (OA) results in improved patient-reported pain and function scores. <br> <b>Purpose:</b> To measure the effects of PRP and high molecular weight hyaluronan (HA) on the expression of anabolic and catabolic genes and on the secretion of nociceptive and inflammatory mediators from OA cartilage and synoviocytes. <br> <b>Study design:</b> Controlled laboratory study. <br> <b>Methods:</b> Synovium and cartilage harvested from patients undergoing total knee arthroplasty were co-cultured with media of PRP or HA. Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and IL-1β were measured in the media by enzyme-linked immunosorbent assay. Hyaluronan synthase-2 (HAS-2), matrix metalloproteina
Original languageEnglish
Pages (from-to)35-41
JournalAmerican Journal of Sports Medicine
StatePublished - Jan 2014

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