The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system

Suyeon Kim, Morvarid Soltani-Bejnood, Annie Quignard-Boulange, Florence Massiera, Michele Teboul, Gerard Ailhaud, Jung Han Kim, Naima Moustaid-Moussa, Brynn H. Voy

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Background. The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results. A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt-KO mice, while plasma adiponectin levels were increased. aP2-Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agt mice.Conclusion. These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.

Original languageEnglish
Article number27012
JournalJournal of Biomedicine and Biotechnology
Volume2006
DOIs
StatePublished - 2006

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