TY - JOUR
T1 - The adipose renin-angiotensin system modulates systemic markers of insulin sensitivity and activates the intrarenal renin-angiotensin system
AU - Kim, Suyeon
AU - Soltani-Bejnood, Morvarid
AU - Quignard-Boulange, Annie
AU - Massiera, Florence
AU - Teboul, Michele
AU - Ailhaud, Gerard
AU - Kim, Jung Han
AU - Moustaid-Moussa, Naima
AU - Voy, Brynn H.
N1 - Funding Information:
Kim Suyeon skim@jax.org 1 Soltani-Bejnood Morvarid mbejnood@utk.edu 1 Quignard-Boulange Annie quignard@bhdc.jussieu.fr 3 Massiera Florence florence.massiera@unice.fr 4 Teboul Michele michel.teboul@unice.fr 4 Ailhaud Gerard gerard.ailhaud@unice.fr 4 Kim Jung Han jhkim@utk.edu 1 Moustaid-Moussa Naima moustaid@utk.edu 1 Voy Brynn H. voybh@ornl.gov 2 1 Department of Nutrition and Agricultural Experiment Station University of Tennessee Knoxville, TN 37996 USA tennessee.edu 2 Life Sciences Division Oak Ridge National Laboratory Oak Ridge, TN 37831 USA ornl.gov 3 Centre Biomédical des Cordeliers INSERM U671-IFR58 Paris 75270 France 4 Centre de Biochimie CNRS 6543 Nice 06108 France 2006 02 08 2006 2006 06 04 2006 17 07 2006 18 07 2006 2006 Copyright © 2006 Suyeon Kim et al. This is an open access article distributed under the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background . The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results . A panel of mouse models including mice lacking angiotensinogen, Agt ( Agt -KO), mice expressing Agt solely in adipose tissue (aP2- Agt/Agt -KO), and mice overexpressing Agt in adipose tissue (aP2- Agt ) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt -KO mice, while plasma adiponectin levels were increased. aP2- Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2- Agt mice. Conclusion . These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity. http://dx.doi.org/10.13039/100000015 U.S. Department of Energy DE-AC05-00OR22725 http://dx.doi.org/10.13039/100000968 American Heart Association TN Agricultural Experiment Station Physicians Medical Education and Research Foundation at Knoxville University of Tennessee
PY - 2006
Y1 - 2006
N2 - Background. The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results. A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt-KO mice, while plasma adiponectin levels were increased. aP2-Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agt mice.Conclusion. These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.
AB - Background. The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results. A panel of mouse models including mice lacking angiotensinogen, Agt (Agt-KO), mice expressing Agt solely in adipose tissue (aP2-Agt/Agt-KO), and mice overexpressing Agt in adipose tissue (aP2-Agt) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt-KO mice, while plasma adiponectin levels were increased. aP2-Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2-Agt mice.Conclusion. These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.
UR - http://www.scopus.com/inward/record.url?scp=34547649343&partnerID=8YFLogxK
U2 - 10.1155/JBB/2006/27012
DO - 10.1155/JBB/2006/27012
M3 - Article
AN - SCOPUS:34547649343
SN - 1110-7243
VL - 2006
JO - Journal of Biomedicine and Biotechnology
JF - Journal of Biomedicine and Biotechnology
M1 - 27012
ER -