Social media is becoming one of the most common deployment methods for antidrug and risk message campaigns. This is largely due to the low cost and high distribution that social media affords. This article argues that the social media approach to antidrug messaging also results in greater attention to the message over time. This article reports results from a study that examined how the combination of a short gain-or-loss framed text message interacts with a subsequent pleasant or unpleasant antidrug video message to influence motivational activation and information processing. Based on previous work investigating how different emotional trajectories in public service announcements (PSAs) elicit different patterns of motivational activation and cognitive processing, it was predicted, and found, that emotionally incongruent combinations of the text frame and video content resulted in the coactivation of the motivational systems. Placing a gain frame before a video message affects the overall processing of the subsequent message such that even an unpleasant message is rated more positively and results in a pattern of resource availability more like what we see for pleasant messages. Motivational activation and the subsequent effects on cognitive and emotional reactions are discussed within the context of multi-modal anti-drug campaigns.