Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming staphylococcus aureus

Wael A. Elmasri; Tianjiao Yang; Phat Tran; Mohamed Elamir F. Hegazy; Abdul N. Hamood; Yehia Mechref; Paul W. Paré

doi:10.1021/np5004092

Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming staphylococcus aureus

Wael A. Elmasri, Tianjiao Yang, Phat Tran, Mohamed Elamir F. Hegazy, Abdul N. Hamood, Yehia Mechref, Paul W. Paré

Chemistry and Biochemistry

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated from a CH₂Cl₂-MeOH extract of the aerial parts of the plant and included iridoid and phenylethanol glycosides and a monoterpenoid, together with nine known compounds. The structures were elucidated based on standard spectroscopic (UV, ¹H and ¹³C NMR), 2D NMR (¹H-¹H COSY, HMQC, HMBC, and NOESY), and/or LC-ESIMS/MS data analyses. Inhibition of the biofilm-forming strain Staphylococcus aureus was observed with exposure to compounds 7 and 8.

Original language	English
Pages (from-to)	2-9
Number of pages	8
Journal	Journal of Natural Products
Volume	78
Issue number	1
DOIs	https://doi.org/10.1021/np5004092
State	Published - Jan 23 2015

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title = "Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming staphylococcus aureus",

abstract = "The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated from a CH2Cl2-MeOH extract of the aerial parts of the plant and included iridoid and phenylethanol glycosides and a monoterpenoid, together with nine known compounds. The structures were elucidated based on standard spectroscopic (UV, 1H and 13C NMR), 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY), and/or LC-ESIMS/MS data analyses. Inhibition of the biofilm-forming strain Staphylococcus aureus was observed with exposure to compounds 7 and 8.",

author = "Elmasri, {Wael A.} and Tianjiao Yang and Phat Tran and Hegazy, {Mohamed Elamir F.} and Hamood, {Abdul N.} and Yehia Mechref and Par{\'e}, {Paul W.}",

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Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming staphylococcus aureus. / Elmasri, Wael A.; Yang, Tianjiao; Tran, Phat; Hegazy, Mohamed Elamir F.; Hamood, Abdul N.; Mechref, Yehia ; Paré, Paul W.

In: Journal of Natural Products, Vol. 78, No. 1, 23.01.2015, p. 2-9.

Research output: Contribution to journal › Article › peer-review

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AU - Mechref, Yehia

AU - Paré, Paul W.

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