Teucrium polium phenylethanol and iridoid glycoside characterization and flavonoid inhibition of biofilm-forming staphylococcus aureus

Wael A. Elmasri, Tianjiao Yang, Phat Tran, Mohamed Elamir F. Hegazy, Abdul N. Hamood, Yehia Mechref, Paul W. Paré

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The chemical composition and biofilm regulation of 15 metabolites from Teucrium polium are reported. Compounds were isolated from a CH2Cl2-MeOH extract of the aerial parts of the plant and included iridoid and phenylethanol glycosides and a monoterpenoid, together with nine known compounds. The structures were elucidated based on standard spectroscopic (UV, 1H and 13C NMR), 2D NMR (1H-1H COSY, HMQC, HMBC, and NOESY), and/or LC-ESIMS/MS data analyses. Inhibition of the biofilm-forming strain Staphylococcus aureus was observed with exposure to compounds 7 and 8.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalJournal of Natural Products
Volume78
Issue number1
DOIs
StatePublished - Jan 23 2015

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