Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review

Mohamed Elamir F. Hegazy; Abdelsamed I. Elshamy; Tarik A. Mohamed; Taha A. Hussien; Soleiman E. Helaly; Nahla S. Abdel-Azim; Khaled A. Shams; Abdelaaty A. Shahat; Wafaa A. Tawfik; Alaa M. Shahen; Abdessamad Debbab; Hesham R. El Saedi; Abou El Hamd H. Mohamed; Faiza M. Hammouda; Mahmoud Sakr; Paul W. Paré; Thomas Efferth

doi:10.1080/07388551.2019.1681932

Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review

Mohamed Elamir F. Hegazy, Abdelsamed I. Elshamy, Tarik A. Mohamed, Taha A. Hussien, Soleiman E. Helaly, Nahla S. Abdel-Azim, Khaled A. Shams, Abdelaaty A. Shahat, Wafaa A. Tawfik, Alaa M. Shahen, Abdessamad Debbab, Hesham R. El Saedi, Abou El Hamd H. Mohamed, Faiza M. Hammouda, Mahmoud Sakr, Paul W. Paré, Thomas Efferth

Chemistry and Biochemistry

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988–2019).

Original language	English
Pages (from-to)	64-82
Number of pages	19
Journal	Critical Reviews in Biotechnology
Volume	40
Issue number	1
DOIs	https://doi.org/10.1080/07388551.2019.1681932
State	Published - Jan 2 2020

Keywords

Pharmaceutical products
Terpenoid
active natural product derivatives
enzymatic biotransformations
natural metabolites
plant cell cultures

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10.1080/07388551.2019.1681932

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Hegazy, M. E. F., Elshamy, A. I., Mohamed, T. A., Hussien, T. A., Helaly, S. E., Abdel-Azim, N. S., Shams, K. A., Shahat, A. A., Tawfik, W. A., Shahen, A. M., Debbab, A., El Saedi, H. R., Mohamed, A. E. H. H., Hammouda, F. M., Sakr, M., Paré, P. W., & Efferth, T. (2020). Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review. Critical Reviews in Biotechnology, 40(1), 64-82. https://doi.org/10.1080/07388551.2019.1681932

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title = "Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review",

abstract = "Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988–2019).",

keywords = "Pharmaceutical products, Terpenoid, active natural product derivatives, enzymatic biotransformations, natural metabolites, plant cell cultures",

author = "Hegazy, {Mohamed Elamir F.} and Elshamy, {Abdelsamed I.} and Mohamed, {Tarik A.} and Hussien, {Taha A.} and Helaly, {Soleiman E.} and Abdel-Azim, {Nahla S.} and Shams, {Khaled A.} and Shahat, {Abdelaaty A.} and Tawfik, {Wafaa A.} and Shahen, {Alaa M.} and Abdessamad Debbab and {El Saedi}, {Hesham R.} and Mohamed, {Abou El Hamd H.} and Hammouda, {Faiza M.} and Mahmoud Sakr and Par{\'e}, {Paul W.} and Thomas Efferth",

note = "Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2020",

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doi = "10.1080/07388551.2019.1681932",

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Hegazy, MEF, Elshamy, AI, Mohamed, TA, Hussien, TA, Helaly, SE, Abdel-Azim, NS, Shams, KA, Shahat, AA, Tawfik, WA, Shahen, AM, Debbab, A, El Saedi, HR, Mohamed, AEHH, Hammouda, FM, Sakr, M, Paré, PW & Efferth, T 2020, 'Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review', Critical Reviews in Biotechnology, vol. 40, no. 1, pp. 64-82. https://doi.org/10.1080/07388551.2019.1681932

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T1 - Terpenoid bio-transformations and applications via cell/organ cultures

T2 - a systematic review

AU - Hegazy, Mohamed Elamir F.

AU - Elshamy, Abdelsamed I.

AU - Mohamed, Tarik A.

AU - Hussien, Taha A.

AU - Helaly, Soleiman E.

AU - Abdel-Azim, Nahla S.

AU - Shams, Khaled A.

AU - Shahat, Abdelaaty A.

AU - Tawfik, Wafaa A.

AU - Shahen, Alaa M.

AU - Debbab, Abdessamad

AU - El Saedi, Hesham R.

AU - Mohamed, Abou El Hamd H.

AU - Hammouda, Faiza M.

AU - Sakr, Mahmoud

AU - Paré, Paul W.

AU - Efferth, Thomas

PY - 2020/1/2

Y1 - 2020/1/2

N2 - Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988–2019).

AB - Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988–2019).

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KW - Terpenoid

KW - active natural product derivatives

KW - enzymatic biotransformations

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Terpenoid bio-transformations and applications via cell/organ cultures: a systematic review

Abstract

Keywords

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