TY - JOUR
T1 - Terpenoid bio-transformations and applications via cell/organ cultures
T2 - a systematic review
AU - Hegazy, Mohamed Elamir F.
AU - Elshamy, Abdelsamed I.
AU - Mohamed, Tarik A.
AU - Hussien, Taha A.
AU - Helaly, Soleiman E.
AU - Abdel-Azim, Nahla S.
AU - Shams, Khaled A.
AU - Shahat, Abdelaaty A.
AU - Tawfik, Wafaa A.
AU - Shahen, Alaa M.
AU - Debbab, Abdessamad
AU - El Saedi, Hesham R.
AU - Mohamed, Abou El Hamd H.
AU - Hammouda, Faiza M.
AU - Sakr, Mahmoud
AU - Paré, Paul W.
AU - Efferth, Thomas
N1 - Funding Information:
Prof Mohamed Hegazy gratefully acknowledges the financial support from Alexander von Humboldt Foundation “Georg Foster Research Fellowship for Experienced Researchers.” HRE thanks Swedish Research links grant 2016-05885 (VR for the years 2017–2019). Dr. Elshamy wish to gratefully acknowledges the Takeda Science Foundation, Japan.
Publisher Copyright:
© 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2020/1/2
Y1 - 2020/1/2
N2 - Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988–2019).
AB - Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988–2019).
KW - Pharmaceutical products
KW - Terpenoid
KW - active natural product derivatives
KW - enzymatic biotransformations
KW - natural metabolites
KW - plant cell cultures
UR - http://www.scopus.com/inward/record.url?scp=85074709115&partnerID=8YFLogxK
U2 - 10.1080/07388551.2019.1681932
DO - 10.1080/07388551.2019.1681932
M3 - Review article
C2 - 31663377
AN - SCOPUS:85074709115
VL - 40
SP - 64
EP - 82
JO - Critical Reviews in Biotechnology
JF - Critical Reviews in Biotechnology
SN - 0738-8551
IS - 1
ER -