Targets and Mechanisms of Geminivirus Silencing Suppressor Protein AC2

Karuppannan Veluthambi, Sukumaran Sunitha

Research output: Contribution to journalReview articlepeer-review


Geminiviruses are plant DNA viruses that infect a wide range of plant species and cause significant losses to economically important food and fiber crops. The single-stranded geminiviral genome encodes a small number of proteins which act in an orchestrated manner to infect the host. The fewer proteins encoded by the virus are multifunctional, a mechanism uniquely evolved by the viruses to balance the genome-constraint. The host-mediated resistance against incoming virus includes post-transcriptional gene silencing, transcriptional gene silencing, and expression of defense responsive genes and other cellular regulatory genes. The pathogenicity property of a geminiviral protein is linked to its ability to suppress the host-mediated defense mechanism. This review discusses what is currently known about the targets and mechanism of the viral suppressor AC2/AL2/transcriptional activator protein (TrAP) and explore the biotechnological applications of AC2.

Original languageEnglish
Article number645419
JournalFrontiers in Microbiology
StatePublished - Apr 9 2021


  • AC2/C2
  • biopharming
  • geminivirus
  • genome-editing
  • silencing suppressor
  • suppressor protein
  • transcriptional activator


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