TY - JOUR
T1 - Targeting mitochondrial bioenergetics as a promising therapeutic strategy in metabolic and neurodegenerative diseases
AU - Bhatti, Gurjit Kaur
AU - Gupta, Anshika
AU - Pahwa, Paras
AU - Khullar, Naina
AU - Singh, Satwinder
AU - Navik, Umashanker
AU - Kumar, Shashank
AU - Mastana, Sarabjit Singh
AU - Reddy, Arubala P.
AU - Reddy, P. Hemachandra
AU - Bhatti, Jasvinder Singh
N1 - Publisher Copyright:
© 2022 Chang Gung University
PY - 2022/10
Y1 - 2022/10
N2 - Mitochondria are the organelles that generate energy for the cells and act as biosynthetic and bioenergetic factories, vital for normal cell functioning and human health. Mitochondrial bioenergetics is considered an important measure to assess the pathogenesis of various diseases. Dysfunctional mitochondria affect or cause several conditions involving the most energy-intensive organs, including the brain, muscles, heart, and liver. This dysfunction may be attributed to an alteration in mitochondrial enzymes, increased oxidative stress, impairment of electron transport chain and oxidative phosphorylation, or mutations in mitochondrial DNA that leads to the pathophysiology of various pathological conditions, including neurological and metabolic disorders. The drugs or compounds targeting mitochondria are considered more effective and safer for treating these diseases. In this review, we make an effort to concise the available literature on mitochondrial bioenergetics in various conditions and the therapeutic potential of various drugs/compounds targeting mitochondrial bioenergetics in metabolic and neurodegenerative diseases.
AB - Mitochondria are the organelles that generate energy for the cells and act as biosynthetic and bioenergetic factories, vital for normal cell functioning and human health. Mitochondrial bioenergetics is considered an important measure to assess the pathogenesis of various diseases. Dysfunctional mitochondria affect or cause several conditions involving the most energy-intensive organs, including the brain, muscles, heart, and liver. This dysfunction may be attributed to an alteration in mitochondrial enzymes, increased oxidative stress, impairment of electron transport chain and oxidative phosphorylation, or mutations in mitochondrial DNA that leads to the pathophysiology of various pathological conditions, including neurological and metabolic disorders. The drugs or compounds targeting mitochondria are considered more effective and safer for treating these diseases. In this review, we make an effort to concise the available literature on mitochondrial bioenergetics in various conditions and the therapeutic potential of various drugs/compounds targeting mitochondrial bioenergetics in metabolic and neurodegenerative diseases.
KW - Antioxidants
KW - Bioenergetics
KW - Electron transport chain
KW - Mitochondrial dysfunction
KW - Oxidative stress
UR - http://www.scopus.com/inward/record.url?scp=85134844024&partnerID=8YFLogxK
U2 - 10.1016/j.bj.2022.05.002
DO - 10.1016/j.bj.2022.05.002
M3 - Review article
C2 - 35568318
AN - SCOPUS:85134844024
SN - 2319-4170
VL - 45
SP - 733
EP - 748
JO - Biomedical Journal
JF - Biomedical Journal
IS - 5
ER -