Target inhibition maps based on responses to kinase inhibitors

Noah Berlow, Ranadip Pal

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

The prediction of tumor sensitivity to targeted drugs remains a major challenge in the design of optimal therapeutic strategies. This chapter presents a computational modeling approach to infer target inhibition maps based on responses of the tumor culture to a range of kinase inhibitors. The kinase inhibition profiles of the targeted drugs and the functional responses are utilized to infer potential tumor proliferation circuits that can assist in generation of synergistic drug combinations.

Original languageEnglish
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages507-522
Number of pages16
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1636
ISSN (Print)1064-3745

Keywords

  • Drug sensitivity
  • Modeling
  • Target inhibition maps
  • Tumor proliferation pathways

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