TY - JOUR
T1 - Tansley review no. 120
T2 - Pathways to abscisic acid-regulated gene expression
AU - Rock, C. D.
PY - 2000
Y1 - 2000
N2 - Recent progress in ABA signalling is summarized from the perspectives gained by genetic (mutant) analysis, 'reverse genetics' (starting from unknown ABA-inducible sequences and working backwards) and biochemical studies. What emerges is a cell-biological model of overlapping tissue-specific stress (e.g. drought, salt and cold) and developmental (e.g. sugars and other hormones) response pathways that integrate into responses mediated by ABA, including but not limited to seed maturation, dormancy, inhibition of cell division and germination, stomatal closure and changes in gene expression leading to stress adaptation. ABA signalling involves putative ABA receptors (extracellular or intracellular), cell-surface membrane proteins including ion channels, glycoproteins and membrane trafficking components, secondary messengers such as phosphatidic acid, inositol 1,4,5-trisphosphate, cyclic ADP-ribose and calcium, and protein phosphorylation/dephosphorylation cascades leading to chromatin remodelling and binding of transcriptional complexes to ABA-responsive promoter elements. The large gaps in our understanding of complex regulatory networks such as ABA signalling can be best addressed by multidisciplinary, integrated approaches such as those discussed.
AB - Recent progress in ABA signalling is summarized from the perspectives gained by genetic (mutant) analysis, 'reverse genetics' (starting from unknown ABA-inducible sequences and working backwards) and biochemical studies. What emerges is a cell-biological model of overlapping tissue-specific stress (e.g. drought, salt and cold) and developmental (e.g. sugars and other hormones) response pathways that integrate into responses mediated by ABA, including but not limited to seed maturation, dormancy, inhibition of cell division and germination, stomatal closure and changes in gene expression leading to stress adaptation. ABA signalling involves putative ABA receptors (extracellular or intracellular), cell-surface membrane proteins including ion channels, glycoproteins and membrane trafficking components, secondary messengers such as phosphatidic acid, inositol 1,4,5-trisphosphate, cyclic ADP-ribose and calcium, and protein phosphorylation/dephosphorylation cascades leading to chromatin remodelling and binding of transcriptional complexes to ABA-responsive promoter elements. The large gaps in our understanding of complex regulatory networks such as ABA signalling can be best addressed by multidisciplinary, integrated approaches such as those discussed.
KW - ABA
KW - Hormone
KW - Plasma membrane
KW - Receptor
KW - Regulation of gene expression
KW - Secondary messenger
KW - Signal trasduction
KW - Stress
UR - http://www.scopus.com/inward/record.url?scp=0034485567&partnerID=8YFLogxK
U2 - 10.1046/j.1469-8137.2000.00769.x
DO - 10.1046/j.1469-8137.2000.00769.x
M3 - Review article
AN - SCOPUS:0034485567
SN - 0028-646X
VL - 148
SP - 357
EP - 396
JO - New Phytologist
JF - New Phytologist
IS - 3
ER -