Systematic HRAS Amplification in Ovary-independent Mammary Tumors: Correlation with Progressively Anaplastic Phenotypes

C. Marcelo Aldaz, Lauren S. Gollahon, Aaron Chen

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases the amplified sequences did not reside at the native chromosome 1 locus but were localized in a novel marker chromosome. The model described has potential as a reproducible system for the study of the chromosomal and cellular mechanisms operative uin vivo” for oncogene amplification.

Original languageEnglish
Pages (from-to)5339-5344
Number of pages6
JournalCancer Research
Volume53
Issue number22
StatePublished - Nov 1993

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