Abstract
Progression of well differentiated rat mammary adenocarcinomas to very anaplastic phenotypes was found to correlate with a systematic and significant amplification of a mutant HRAS allele. Tumors with high amplification levels of this oncogene were analyzed by chromosomal in situ hybridization; in four of the cases the amplified sequences did not reside at the native chromosome 1 locus but were localized in a novel marker chromosome. The model described has potential as a reproducible system for the study of the chromosomal and cellular mechanisms operative uin vivo” for oncogene amplification.
| Original language | English |
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| Pages (from-to) | 5339-5344 |
| Number of pages | 6 |
| Journal | Cancer Research |
| Volume | 53 |
| Issue number | 22 |
| State | Published - Nov 1993 |